Results 31 to 40 of about 46,134 (262)
Making masks for Maui: Keeping the macro task in mind [PDF]
, 2007 New Zealand primary school children in technology lessons often design and create an artifact in response to a scenario that relates to their interests and experiences. Usually the task is undertaken over several days.
Cowie, Bronwen, Moreland, Judy
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Dual-Track Lifelong Machine Learning-Based Fine-Grained Product Quality Analysis
Applied Sciences, 2023 Artificial intelligence (AI) systems are becoming wiser, even surpassing human performances in some fields, such as image classification, chess, and Go. However, most high-performance AI systems, such as deep learning models, are black boxes (i.e., only ...
Xianbin Hong +6 more
doaj +1 more source
Multimodal music information processing and retrieval: survey and future challenges
, 2019 Towards improving the performance in various music information processing tasks, recent studies exploit different modalities able to capture diverse aspects of music.
Avanzini, Federico +2 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu +14 more
wiley +1 more source
Indicators for managing human centred manufacturing [PDF]
, 2013 Establishing indicators for managing human factors (HF) aspects in the design of production systems remains a challenge. We address the problem in two dimensions – firstly, what aspects of HF are to be considered, and secondly, where in the development ...
Greig, Michael +3 more
core
Sociocultural theory and its application to CALL: A study of the computer and its relevance as a mediational tool in the process of collaborative activity [PDF]
, 2006 This study in the field of Second Language Acquisition (SLA) was conducted in a Spanish as a foreign language classroom. The study investigates dyadic face-to-face collaborative dialogue at the computer from a sociocultural perspective.
Gánem-Gutiérrez, GA
core +1 more source
Arthritis Care &Research, EarlyView.Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah +6 more
wiley +1 more source