Results 351 to 360 of about 1,982,911 (405)
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2011
Macrophages are a diverse phenotype of professional phagocytic cells derived from bone-marrow precursors and parent monocytes in the peripheral blood. They are essential for the maintenance and defence of host tissues, doing so by sensing and engulfing particulate matter and, when necessary, initiating a pro-inflammatory response.
Chris P, Verschoor +2 more
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Macrophages are a diverse phenotype of professional phagocytic cells derived from bone-marrow precursors and parent monocytes in the peripheral blood. They are essential for the maintenance and defence of host tissues, doing so by sensing and engulfing particulate matter and, when necessary, initiating a pro-inflammatory response.
Chris P, Verschoor +2 more
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Granuloma macrophage differentiation [PDF]
Nature Reviews Immunology, 2016 Multinuclear granuloma macrophages arise through a distinct differentiation pathway mediated by chronic TLR2 signalling, rather than by cell fusion.
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BioEssays, 1995
AbstractThe macrophage plays an important role in host development and physiology, and in pathogenesis of many infectious, immunologic and degenerative disease processes. It displays marked heterogeneity of phenotype in different tissues, reflecting local interactions with other cell types, and contributes to host homeostasis through a varied ...
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AbstractThe macrophage plays an important role in host development and physiology, and in pathogenesis of many infectious, immunologic and degenerative disease processes. It displays marked heterogeneity of phenotype in different tissues, reflecting local interactions with other cell types, and contributes to host homeostasis through a varied ...
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Cancer and Metastasis Reviews, 1990
The uncontrolled growth of metastases resistant to conventional therapeutic modalities is a major cause of death from cancer. Data from our laboratory and others indicate that metastases arise from the nonrandom spread of specialized malignant cells that preexist within a primary neoplasm.
Isaiah J. Fidler +4 more
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The uncontrolled growth of metastases resistant to conventional therapeutic modalities is a major cause of death from cancer. Data from our laboratory and others indicate that metastases arise from the nonrandom spread of specialized malignant cells that preexist within a primary neoplasm.
Isaiah J. Fidler +4 more
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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
Science, 1993Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. With the use of naïve, ovalbumin-specific alpha beta T cell receptor transgenic T cell, it was found that heat-killed Listeria ...
C. Hsieh +5 more
semanticscholar +1 more source
Atherosclerosis and Macrophages
Acta Pathologica Japonica, 1989Atherosclerosis is undoubtedly a disease of many facets and in this review we have merely touched one angle of this issue. The best‐established cause of the disease is hyper‐cholesterolemia. Since the important role of macrophages in lipoprotein metabolism has been confirmed, current interest is focused on the role of macrophages in atherosclerosis ...
Jianglin Fan +3 more
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Alternative activation of macrophages: an immunologic functional perspective.
Annual Review of Immunology, 2009Macrophages are innate immune cells with well-established roles in the primary response to pathogens, but also in tissue homeostasis, coordination of the adaptive immune response, inflammation, resolution, and repair. These cells recognize danger signals
F. Martínez, L. Helming, S. Gordon
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Frontiers in Bioscience, 2008
Macrophages are ubiquitous cells physiologically involved in a variety of processes including pathogen destruction, inflammation, tissue repair and remodeling. They have a highly plastic phenotype and their functional polarization is determined by cytokines and factors found within local microenvironments.
Alessandra Nardin, Jean-Pierre Abastado
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Macrophages are ubiquitous cells physiologically involved in a variety of processes including pathogen destruction, inflammation, tissue repair and remodeling. They have a highly plastic phenotype and their functional polarization is determined by cytokines and factors found within local microenvironments.
Alessandra Nardin, Jean-Pierre Abastado
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Mechanisms of phagocytosis in macrophages.
Annual Review of Immunology, 1999Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic ...
A. Aderem, D. Underhill
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Cellular Immunology, 1983
It is a pleasure and a privilege to be here today to honor Lewis Thomas. As I look out on this distinguished audience and see so many good friends, it brings on an attack of nostalgia for the early sixties on the sixth floor of Building D in Bellevue. Those years with Jerry and Lew were some of the most exciting and satisfying of my career. The sixties
Roberta A. David +4 more
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It is a pleasure and a privilege to be here today to honor Lewis Thomas. As I look out on this distinguished audience and see so many good friends, it brings on an attack of nostalgia for the early sixties on the sixth floor of Building D in Bellevue. Those years with Jerry and Lew were some of the most exciting and satisfying of my career. The sixties
Roberta A. David +4 more
openaire +3 more sources