Results 121 to 130 of about 451,441 (295)

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Potassium Migration of Chestnut Shell Ashes Under Oxidizing Atmosphere and Its Modification Mechanism by Additives

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Biomass energy plays a critical role in alleviating environmental pressures. However, its relatively high content of alkali metals (especially for potassium) would cause ash‐related issues during combustion. To mitigate these issues, the potassium migration behaviors during chestnut shell (CS) conversion and the modification mechanisms of ...
Meijie Zhou, Weijie Guo, Fenghai Li, Xuefei Liu, Ziqiang Yang, Mingjie Ma, Yitian Fang   +6 more
wiley   +1 more source

Enabling the study of gene function in gymnosperms: Virus‐induced gene silencing in Ephedra tweedieana

Applications in Plant Sciences, EarlyView.
Abstract Premise As the sister clade to angiosperms, extant gymnosperms are crucial for reconstructing ancestral gene regulatory networks in seed plants. This highlights the need for model systems representing each of their distinct lineages. However, tools to quickly and effectively investigate gene function in gymnosperms are still limited due to the
Anthony G. K. Garcia, Jo Trang Bùi, Todd P. Michael, Stefanie M. Ickert‐Bond, Verónica S. Di Stilio   +4 more
wiley   +1 more source

Coherence‐Gated Wrapped‐Phase InSAR With Matrix‐Based Uncertainty Diagnostics for Burial‐Mound Hotspot Ranking (Sicily, Italy)

Archaeological Prospection, EarlyView.
ABSTRACT Burial mounds are key elements of Mediterranean funerary landscapes, but in intensively cultivated coastal plains their low‐relief expression is easily obscured by ploughing, levelling and rapidly changing surface conditions, making single‐date observations unreliable.
Salvatore Polverino, Hourakhsh Ahmadnia, Rokhsaneh Rahbarianyazd Ahmadnia   +2 more
wiley   +1 more source

Over‐the‐Top Anterior Cruciate Ligament Reconstruction With Lateral Extra‐articular Tenodesis in Pediatric Athletes Provides Excellent Functional Outcomes and Preserves Growth Plate Symmetry

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess clinical and radiological outcomes of pediatric anterior cruciate ligament (ACL) reconstruction using the over‐the‐top technique (OTT) combined with the lateral extra‐articular tenodesis (LET) technique in skeletally immature patients, providing insights into its safety, efficacy, and effects on the growing knee.
Abel Gomez‐Caceres, Ivan Medina‐Porqueres, Manuel Benavides Propp, Almudena Perez Lara, Ignacio Vieitez‐Riestra, Raphael Pierre Idiart‐Charrier, Iskandar Tamimi‐Mariño   +6 more
wiley   +1 more source

A Phase I, Randomized, SAD, MAD, and PK Study of Risvodetinib in Older Adults and Parkinson’s Disease

Journal of Parkinson’s Disease
Background: Pre-clinical studies suggest that c-Abl activation may play an important role in the etiology of Parkinson’s disease, making c-Abl an important target to evaluate for potential disease-modification.
Milton H. Werner, C. Warren Olanow, Andrew McGarry, Christopher Meyer, Sydney Kruger, Carl Klint, Jacqueline Pellecchia, Shannon Walaker, Larry Ereshefsky, Lawrence Blob, Howard Hassman, Carlos Rodriguez, Emil Samara, Beth Safirstein, Aaron Ellenbogen   +14 more
doaj   +1 more source

From concept to community of practice in anatomical ethics and professionalism: 5 years of the “Bioethics Unicorns” education initiative

Anatomical Sciences Education, EarlyView.
Abstract The topics of ethics and professionalism in anatomy have only recently gained prominence within the discipline, reflecting trends in medical and health professions education and an increasing awareness of societal expectations around the use of the dead.
Jon Cornwall, Sabine Hildebrandt, Thomas Champney   +2 more
wiley   +1 more source

The role of metaphor in creating polysemy complexes in Jordanian Arabic and American English

Russian Journal of Linguistics
Most papers written on polysemy focus on sense overlaps and lexical ambiguity, yet studies that explore the possibility of establishing a polysemic complex and explaining how the new interpretations arise through metaphor are almost non-existent in ...
Aseel Zibin, Lama Khalifah, Abdel Rahman Mitib Altakhaineh   +2 more
doaj   +1 more source

Immersive reality capabilities of relieving hiraeth

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Understanding how immersive experiences foster a sense of presence sufficient to rival real‐world experiences remains an open research area. Prior work has largely examined episodic memory recall in simulated environments, but less is known about how immersive technologies can reconnect individuals with personal memories.
Erica Mi, Fred Fonseca
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of inhaled molgramostim in healthy people

BMJ Open Respiratory Research
Background Inhaled molgramostim, a form of recombinant human granulocyte–macrophage colony stimulating factor (GM-CSF), is a promising investigational pharmacotherapy for autoimmune pulmonary alveolar proteinosis (aPAP); however, its pharmacology in ...
Bruce C Trapnell, Brenna C Carey, Brian R Robinson   +2 more
doaj   +1 more source