Results 151 to 160 of about 450,506 (276)

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Interdaily variability of rest-activity patterns and risk of dementia in older adults: The ARIC Neurocognitive Study. [PDF]

Alzheimers Dement (N Y)
Chamberlin KW, Etzkorn LH, Davoudi A, Wang W, Dougherty RJ, Palta P, Wanigatunga AA, Windham BG, Chen LY, Spira AP, Schrack JA.   +10 more
europepmc   +1 more source

Caught in the fire: An accidental ethnography of discomfort in researching sex work

Feminist Anthropology, EarlyView.
Abstract Drawing on fifteen years of engagement with researching Israel's sex industry, this article uses accidental ethnography to propose discomfort‐as‐method for feminist anthropology. I argue that discomfort is not a by‐product of fieldwork but a constitutive condition that disciplines researchers and shapes what can be known.
Yeela Lahav‐Raz
wiley   +1 more source

“I Need to Be Prepared”: EFL Teachers in Korea and GenAI's Influence on Their Professional Identities

Future in Educational Research, EarlyView.
ABSTRACT The proliferation of generative artificial intelligent (GenAI) models and tools are revolutionizing how existing practices are transformed across multiple industries, including English language education. Simultaneously, the capabilities of these models are shaping how teachers reevaluate their roles as educators, especially in high‐stakes ...
Josh Hayes, A. Jane Loper
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Phase 1 dose-escalation study of IBI324, a VEGF-A/Ang-2 bispecific antibody, for the treatment of diabetic macular oedema. [PDF]

BMJ Open Ophthalmol
Wang Z, Sun J, Liu K, Tao L, Liu Q, Wu M, Lu S, Deng J, Li L, Qian L, Li X, Sun X.   +11 more
europepmc   +1 more source

Challenges in the future of cancer screening

International Journal of Cancer, EarlyView.
Abstract The purpose of cancer screening is to reduce mortality, and ideally incidence, from the cancer screened for. Until recently, cancer screening has been offered to all persons in pre‐defined sex‐ and age‐groups. The exception is lung screening which is targeted to high‐risk individuals.
Elsebeth Lynge, Berit Andersen, Stig E. Bojesen, Lone Kjeld Petersen, Mickael Bech, Martin Bøgsted, Mie Seest Dam, Søren Egstrand, Anne Mette Fløe Hvass, Camilla J. Kobylecki, Kristina Lång, Mads Nielsen, Giorgi Paolo Rossi, Michael Stenger, Ilse Vejborg, Future of Cancer Screening Working Group, Vibe Munk Bertelsen, Janne Bigaard, Karen Omann Binderup, Lennart Friis‐Hansen, Stine Bisgaard Greve, Jessica Xin Hjaltelin, Rikke Hedegaard Jensen, Gitte Jessing, Pia Kirkegaard, Mette Hartmann Nonboe, Tina Bech Olesen, Katrine Stolberg, Signe Bülow Therkildsen, Mette Kielsholm Thomsen   +29 more
wiley   +1 more source

Measurement of the Distance between the Mitral Annulus and the Left Circumflex Coronary Artery Using Multiplanar Reconstruction of Intraoperative Transoesophageal Echocardiography Images. [PDF]

Interdiscip Cardiovasc Thorac Surg
Kuroda Y, Soga Y, Matsuo T, Tsumaru S, Hakamada K, Wada Y, Kitagata Y, Imada R, Marui A, Ohno N.   +9 more
europepmc   +1 more source

Experiences of disrespect and abuse during childbirth in the World Health Organization European region: A mixed‐method study among 22 countries

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Despite advancements in maternity quality care worldwide, mistreatment of women during childbirth persists. Currently, there is a gap of knowledge on the occurrence of disrespect and abuse during childbirth in the World Health Organization (WHO) European region.
Anna Galle, Helga Berghman, Ilaria Mariani, Maria Verdecchia, Arianna Bomben, Eline Skirnisdottir Vik, Daniela Drandic, Elizabete Pumpure, Raquel Costa, Helen Elden, Céline Miani, Barbara Baranowska, Antigoni Sarantaki, Zalka Drglin, Jelena Radetic, Alina Liepinaitienė, Virginie Rozée, Alessia Abderhalden‐Zellweger, Amira Cerimagic, Martina König‐Bachmann, Ourania Kolokotroni, Ilana Chertok, Maryse Arendt, Stefano delle Vedove, Ingvild Hersoug Nedberg, Magdalena Kurbanovic, Gunta Lazdane, Tiago Miguel Pinto, Karolina Linden, Stephanie Batram‐Zantvoort, Urszula Tataj‐Puzyna, Dimitra Metallinou, Anja Bohinec, Jovana Ružičić, Marija Mizgaitienė, Elise de La Rochebrochard, Michael Gemperle, Imola Simon, Maria Karanikola, Barbara Tasch, Simona Fumagalli, Marzia Lazzerini, on behalf of the IMagiNE EURO study group, Martina König‐Bachmann, Christoph Zenzmaier, Simon Imola, Elisabeth D’Costa, Anna Galle, Silke D’Hauwers, Amira Ćerimagić, Ourania Kolokotroni, Eleni Hadjigeorgiou, Maria Karanikola, Nicos Middleton, Ioli Orphanide Eteocleous, Daniela Drandić, Magdalena Kurbanović, Lenka Laubrova Zirovnicka, Miloslava Kramná, Rozée Virginie, Elise de La Rochebrochard, Kristina Löfgren, Céline Miani, Stephanie Batram‐Zantvoort, Antigoni Sarantaki, Dimitra Metallinou, Aikaterini Lykeridou, Ilana Chertok, Rada Artzi‐Medvedik, Marzia Lazzerini, Emanuelle Pessa Valente, Ilaria Mariani, Arianna Bomben, Stefano Delle Vedove, Sandra Morano, Antonella Nespoli, Simona Fumagalli, Elizabete Pumpure, Dace Rezeberga, Dārta Jakovicka, Gita Jansone‐Šantare, Anna Šibalova, Elīna Voitehoviča, Dārta Krēsliņa, Alina Liepinaitienė, želika Kondrakova, Marija Mizgaitienė, Simona Juciūtė, Maryse Arendt, Barbara Tasch, Enrico Lopriore, Thomas Van den Akker, Ingvild Hersoug Nedberg, Sigrun Kongslien, Eline Skirnisdottir Vik, Barbara Baranowska, Urszula Tataj‐Puzyna, Beata Szlendak, Paulina Pawlicka, Raquel Costa, Catarina Barata, Teresa Santos, Heloísa Dias, Tiago Miguel Pinto, Sofia Marques, Ana Meireles, Joana Oliveira, Mariana Pereira, Maria Arminda Nunes, Marina Ruxandra Otelea, Jelena Radetić, Jovana Ružičić, Zalka Drglin, Anja Bohinec, Serena Brigidi, Alejandra Oliden, Lara Martín Castañeda, Helen Elden, Karolina Linden, Mehreen Zaigham, Claire de Labrusse, Alessia Abderhalden‐Zellweger, Anouck Pfund, Harriet Thorn, Susanne Grylka, Michael Gemperle, Antonia Mueller   +126 more
wiley   +1 more source