Results 71 to 80 of about 1,711 (259)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Charles Frédéric Kuhlmann

Revista CENIC Ciencias Químicas, 2017
Charles Frédéric Kuhlmann (1803-1881), French chemist who carried research in a wide variety of subjects and transformed many of his results into industrial reality that led him to fund a powerful chemical empire that is still active.
Jaime Wisniak
doaj  

English teachers' journeys since the 2020 Iteration of Black Lives Matter

British Educational Research Journal, EarlyView.
Abstract The 2020 resurgence of Black Lives Matter (BLM) mobilised students in England to demand greater representation of racially minoritised voices in English curriculums—a call highlighted by stark inequity: just 1.5% of GCSE texts studied are by racially minoritised authors, despite racially minoritised students comprising 38.0% of the student ...
Adrian Fernandes
wiley   +1 more source

The effect of different media cultures on some growth characteristics of pot marigold (Calendula officinalis L.) plants under drought stress [PDF]

فیزیولوژی محیطی گیاهی, 2019
Drought is one of important environmental stresses that cause decreasing of production and yield in arid and semi-arid areas. Aim of this study was using of some amendment compounds in soil to increase marigold plant (Calendula officinalis L.) resistance
Mahsa Bahrampour, Maryam Dehestani-Ardakani, Mostafa Shirmardi, Jalal Gholamnezhad   +3 more
doaj  

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

The Association Between Perpetration of Relational Aggressive Tendencies and Adolescent Antisocial Behavior

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Most research on relational aggression has primarily examined these behaviors among children, with limited exploration of its developmental progression during early adolescence and its associations with antisocial behaviors such as alcohol use, physical aggression, and rule‐breaking conduct.
Briana Amador, Timothy Lawrence, Qiyue Zhang, Ariel McField, Lily Palmer, Oi‐Man Kwok   +5 more
wiley   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

The AI Sustainability Paradox: How Verification and Regulation Synergize to Curb Greenwashing in Emerging Markets

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Artificial intelligence (AI) reflects a paradox for corporate sustainability: it provides tools for genuine socio‐economic improvement and enables greenwashing at scale. This study examines this duality in emerging Asian markets, where rapid AI adoption coincides with evolving regulatory regimes.
Ashutosh Yadav, Simplice A. Asongu
wiley   +1 more source

Developing a Shade Range on Wool by Madder (Rubia cordifolia) Root Extract with Gallnut (Quercus infectoria) as Biomordant

Journal of Natural Fibers, 2017
Environmental issues inspire the revival of natural dyes that exhibit better biodegradability and more compatibility over synthetic ones. This research is aimed to investigate the effect of color and fastness properties on wool yarn substrate with ...
Mohd Yusuf, Shafat Ahmad Khan, Mohd Shabbir, Faqeer Mohammad   +3 more
doaj   +1 more source