Results 111 to 120 of about 2,191,407 (285)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

open access: yesAngewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann   +10 more
wiley   +1 more source

Liquid–Liquid Equilibrium Data for Refined Olive Pomace Oil + Oleic Acid + Ethanol + Water Systems: Application to Solvent Deacidification

open access: yesJournal of the American Oil Chemists' Society, EarlyView.
ABSTRACT This study presents the first experimental liquid–liquid equilibrium (LLE) data for quaternary systems composed of refined olive pomace oil, oleic acid, ethanol, and water at 303.15 K. These data are essential for the design and optimization of solvent‐based deacidification processes, particularly for oils with high free fatty acid (FFA ...
Jacqueline Mansano Ortega   +5 more
wiley   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

open access: yesThe Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Configuration of a singular iconography; the venerable doña SanchaAlfonso, comendadora of Santiago

open access: yesAnales de Historia del Arte, 2009
The modern representation of doña Sancha Alfonso, Alfonso IX of León’s daughter and comendadora of theOrder of Santiago, was its right to be in the transfer of its body, in 1608, fromthe oldMonastery of Santa Eufemia (Palencia) to theMonastery of Santa ...
Jesús Ángel Sánchez Rivera
doaj  

La provincia de Madrid

open access: yes, 1889
Microficha.
Ayala y Raya, Manuel   +2 more
core  

New techniques for old bones: Morphometric and diffeomorphometric analysis of the bony labyrinth of the Reilingen and Ehringsdorf Neandertals

open access: yesThe Anatomical Record, EarlyView.
Abstract Neandertals are known to possess very distinctive traits in their bony labyrinth morphology, such as an inferiorly positioned posterior canal and a very low number of turns in the cochlea. Hence, the inner ear has been often used to assess the Neandertal status of fragmentary fossils.
Alessandro Urciuoli   +6 more
wiley   +1 more source

Viajes por España (Madrid)

open access: yes, 1929
Revista de turismo que se publica como órgano oficial de la Sociedad de Atracción de Forasteros, de Madrid, y subvencionada por el Patronato Nacional de Turismo, siendo no venal. Su periodicidad y paginación es variada y es impresa a dos tintas.

core   +1 more source

Golondrina : comedia en un acto y en prosa

open access: yes, 1898
"Estrenada en el Teatro Lara el 13 de Octubre de 1886"Dedicado a la viuda de PicónLa acción transcurre en Madrid.
Ramos Carrión, Miguel, 1848-1915   +1 more
core  

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

open access: yesThe Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey   +5 more
wiley   +1 more source

Palacios de Madrid : Madrid 2010

open access: yes, 2010
ESP
Lasso de la Vega Zamora, Miguel   +2 more
openaire   +1 more source

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