Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
Harnessing faba bean MAGIC populations for enhanced protein content, yield, and agronomic performance in diverse environments. [PDF]
Abou Khater L +9 more
europepmc +1 more source
Zuranolone: A case study in (regulatory) rush to judgement?
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
wiley +1 more source
Continuously trapped matter-wave interferometry in magic Floquet-Bloch band structures. [PDF]
Chai X +10 more
europepmc +1 more source
Listening to Hong Kong children's perspectives through pretend play
Abstract Quality in early childhood education and care (ECEC) has become an increasing concern in recent years. The issue has been regularly discussed by different stakeholders. However, the rising concern regarding quality in ECEC has not seriously taken into account children's perspectives.
Suzannie K. Y. Leung
wiley +1 more source
Optical See-Through and Video See-Through Head-Mounted Displays for Percutaneous Biopsies: A Comparative Phantom Study. [PDF]
Jacob AM +21 more
europepmc +1 more source
Breaking point: Identifying the factors that predict suspension from school
Abstract School suspensions are associated with adverse educational and psychosocial outcomes, yet little is known about how structural disadvantage, relational factors, health behaviours, well‐being indicators and school‐level factors jointly predict suspension risk in England.
Stephanie Cahill +5 more
wiley +1 more source
Diagnostically competitive performance of a physiology-informed generative multi-task network for contrast-free CT perfusion. [PDF]
Khan W +14 more
europepmc +1 more source
The ecology of hope: Building rainbows in education systems
Abstract Hope is frequently invoked in education, yet rarely theorised. Where it has been theorised, it has been understood in two largely separate ways: as an individual psychological capacity, in the positive‐psychology tradition and as a critical‐emancipatory stance, in the pedagogy of hope.
Jennifer Achari
wiley +1 more source
Identification of a highly expressed gene cluster likely coding for benzene activation enzymes in a methanogenic enrichment culture. [PDF]
Toth CRA +14 more
europepmc +1 more source

