Results 71 to 80 of about 65,100 (261)

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Psychological impact of the modern children’s entertainment industry: a comprehensive analysis of educational, social and emotional aspects

Путеводитель предпринимателя
This study examines the psychological impact of the children’s entertainment industry, focusing on the multisensory environment of entertainment centers and their influence on cognitive and emotional development.
D. S. Gibson
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Hypergolic Copper Cluster‐Based Covalent Organic Frameworks

Advanced Science, EarlyView.
Hpergolic cluster‐based covalent organic framework (Cu3‐CB‐COF), assembled from aldehyde‐functionalized carborane monomers and trinuclear copper clusters, demonstrates a strong synergy between its catalytic copper nodes and energetic carborane backbones.
Yu‐Zhou Qiao, Cai Li, Wen‐Yang Jiao, Guoqiang Sun, Xiao‐Fei Liu, Shuang‐Quan Zang   +5 more
wiley   +1 more source

Analysis of T-Cell Clonality Pattern in Tumor Samples of Breast Cancer Patients

The International Journal of Biological Markers, 2005
Purpose and methods A large body of experimental evidence has confirmed that different tumors, including breast carcinomas, can stimulate specific T-cell-mediated immune responses.
B.M. Cikota, M.V. Branković-Magić, V.S. Jović, S.S. Radulović, Z.M. Magić   +4 more
doaj   +1 more source

Interfacial Growth of 420 nm Ultrathin and Dense MOFs for Composite Electrolyte to Reduce Li+ Conduction Resistance and Inhibit Lithium Dendrite

Advanced Science, EarlyView.
In this work, an interfacial growth method using PVDF‐HFP enables controlled permeation of 2‐methylimidazole to react with Co2+, forming an ultrathin (420 nm) ZIF‐67 layer by precisely tuning the reaction time. This dense layer promotes lithium salt dissociation and suppresses dendrite growth, while its ultrathin nature reduces Li+ transport resistance,
Xinhong Qi, Zhaokai Rui, Shichen Zhang, Yihang Li, Ziyi Xin, Mengjuan Li, Lu Gao, Yuchen He, Xiaobin Jiang, Xiangcun Li, Gaohong He   +10 more
wiley   +1 more source

Identification of antimicrobial peptides from ancient gut microbiomes

Nature Communications
Fecal coprolites preserve ancient microbiomes and are a potential source of extinct but highly efficacious antimicrobial peptides (AMPs). Here, we develop AMPLiT (AMP Lightweight Identification Tool), an efficient tool deployable to portable hardware for
Sizhe Chen, Yue Yuan, Yun Wang, Ye Peng, Hein Min Tun, Zhimin Jiang, Yinglei Miao, Sunjae Lee, Xiaole Yin, Xiaotao Shen, Orlando DeLeon, Eugene B. Chang, Francis Ka Leung Chan, Yang Sun, Siew Chien Ng, Qi Su   +15 more
doaj   +1 more source

Variation in the metagenomic analysis of fecal microbiome composition calls for a standardized operating approach

Microbiology Spectrum
The reproducibility in microbiome studies is limited due to the lack of one gold-standard operating procedure. The aim of this study was to examine the impact of protocol variations on microbiome composition using metagenomic data sets from a single ...
Zhilu Xu, Yun Kit Yeoh, Hein M. Tun, Na Fei, Jingwan Zhang, Mark Morrison, Michael A. Kamm, Jun Yu, Francis Ka Leung Chan, Siew C. Ng   +9 more
doaj   +1 more source

Prognostic Significance of Mutations in Oral Squamous Cell Carcinoma with Human Papilloma virus Infection

The International Journal of Biological Markers, 2007
Purpose The aim of this study was to analyze the prognostic impact of mutated TP53 in patients with oral squamous cell carcinoma (OSCC) whose tumors were infected with human papillomavirus (HPV).
R.J. Kozomara, M.V. Brankovic-Magic, N.R. Jovic, S.M. Stosic, Z.M. Magic   +4 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source