Results 51 to 60 of about 10,003,151 (237)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Geohazard features of the north-western Sicily and Pantelleria

Journal of Maps
We present maps of geohazard features identified across north-western Sicily and Pantelleria in the framework of the Magic project (MArine Geohazard along Italian Coasts), which involved Italian marine geological researchers in 2007-2013.
Attilio Sulli, Marilena Calarco, Mauro Agate, Ludovico Albano, Alessandro Bosman, Giuseppe Di Grigoli, Francesco Gargano, Valeria Lo Presti, Eleonora Martorelli, Valentina Pennino, Andrea Sposato, Elisabetta Zizzo, Giusy Anzelmo, Alessandro Bonfardeci, Daniele Casalbore, Gaspare Ciaccio, Aida Maria Conte, Michela Ingrassia, Sara Innangi, Francesco Interbartolo, Erika Lai, Claudio Lo Iacono, Maurizio Gasparo Morticelli, Carlo Luzzu, Paolo Emanuele Orrù, Fabrizio Pepe, Martina Pierdomenico, Claudia Romagnoli, Daniele Spatola, Francesco Latino Chiocci   +29 more
doaj   +1 more source

Magic Sets for disjunctive Datalog programs [PDF]

, 2012
In this paper, a new technique for the optimization of (partially) bound queries over disjunctive Datalog programs with stratified negation is presented.
Alviano, Mario, Greco, Gianluigi, Faber, Wolfgang, Leone, Nicola, Marco Manna, Gianluigi Greco, Wolfgang Faber, Mario Alviano, Nicola Leone, Ermelinda Oro, Massimo Ruffolo   +10 more
core   +1 more source

magic-sph/magic: release MagIC 6.1

, 2021
Now support input resolution in spectral space directly specifying l_max and m_max. This now also works with m_max /= l_max. Implement support for a linearized version of MagIC to speed-up the estimate of critical Rayleigh numbers. Use it with mode=5 and
LDVDuarte, Thomas Gastine, Johannes W, rraynaud, t-schwaiger, thtassin, Ankit Barik, Bertrand Putigny, Boris Dintrans   +8 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

The Magic lantern.

, 1985
Mode of access: Internet.Reprint. Orginally published weekly: Philadelphia : Benerman & Wilson. Vol. 1, no. 1 (Sept. 1874)-v. 1, no. 8 (Apr. 1875) issued as Vol. 7, no.
Magic Lantern Society of the United States and Canada.
core  

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

The MAGIC telescope

, 2005
MAGIC (Major Atmospheric Gamma Imaging Cherenkov telescope) is presently the largest ground-based gamma ray telescope. MAGIC has been taking data regularly since October 2004 at the Roque de los Muchachos Observatory on the island of La Palma.
MAGIC COLLABORATION, PASCOLI, DONATELLA, C. BIGONGIARI   +2 more
core  

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Magic, a Service Center for Technologies Applied to Manuscripts and Printed Books. Project Overview and Progress Report

Umanistica Digitale
Magic, a three-year interdisciplinary project conducted by the Department of humanities and the Department of physics "Ettore Pancini" of the University of Naples "Federico II", has created and is developing a Service center for the use of cutting-edge ...
Stefania Conte
doaj   +1 more source