Results 31 to 40 of about 931 (160)

Managing risk of non‐indigenous species establishment associated with ballast water discharges from ships with bypassed or inoperable ballast water management systems

Journal of Applied Ecology, Volume 60, Issue 1, Page 193-204, January 2023., 2023
The risk of aquatic invasions and their associated ecological damages can be substantially reduced by using a ballast water management system (BWMS) and/or ballast water exchange (BWE). When a BWMS is inoperable, appropriate mitigation measures should be decided on a trip‐by‐trip basis considering voyage route and reason for BWMS inoperability (when ...
Johanna Bradie, Matteo Rolla, Sarah A. Bailey, Hugh J. MacIsaac   +3 more
wiley   +1 more source

RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations

Cancer Discovery, 2023
Unlike pan-FGFR inhibitors, RLY-4008 was designed to be selective for FGFR2 and induces clinical responses in FGFR2-altered solid tumors without clinically significant FGFR1-mediated hyperphosphatemia and FGFR4-mediated diarrhea.
V. Subbiah, V. Sahai, Dejan Maglic, Kamil Bruderek, B. Touré, Songping Zhao, R. Valverde, Patrick J O'Hearn, D. Moustakas, Heike Schonherr, Nastaran Gerami-Moayed, Alexander M. Taylor, B. M. Hudson, Damian Houde, Debjani Pal, Lindsey Foster, H. Gunaydin, P. Ayaz, Dina A Sharon, L. Goyal, A. Schram, Suneel D. Kamath, C. Sherwin, O. Schmidt-Kittler, K. Jen, F. Ricard, B. Wolf, D. Shaw, D. Bergstrom, J. Watters, Jessica B Casaletto   +30 more
semanticscholar   +1 more source

Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer‐like mice

Aging Cell, Volume 21, Issue 5, May 2022., 2022
Neural progenitor cells (NPC) emerged their roles in endogenous regenerating neurons for Alzheimer's disease (AD) treatments. Clinical genomics data and AD animal model experiments suggested that DMP1 was related to cognitive function and NPC proliferation.
Huimin Zhao, Jie Wei, Yanan Du, Peipei Chen, Xiaoquan Liu, Haochen Liu, for the Alzheimer’s Disease Neuroimaging Initiative   +6 more
wiley   +1 more source

Genotype–phenotype correlates in Joubert syndrome: A review

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 1, Page 72-88, March 2022., 2022
Abstract Joubert syndrome (JS) is a genetically heterogeneous primary ciliopathy characterized by a pathognomonic cerebellar and brainstem malformation, the “molar tooth sign,” and variable organ involvement. Over 40 causative genes have been identified to date, explaining up to 94% of cases. To date, gene‐phenotype correlates have been delineated only
Simone Gana, Valentina Serpieri, Enza Maria Valente   +2 more
wiley   +1 more source

Reducing a Human Factor in Cruise Ships Accidents by Improving Crew Competences [PDF]

TransNav, 2021
In recent decades, there has been noticed a continuous growth of passengers on cruise ships. Technical as well as technological development follow this growth side to side as far as construction, transport of passengers and strict legal regulations are ...
Ana Gundic, Srđan Vujičic, Lovro Maglic, Luka Grbic   +3 more
doaj   +1 more source

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Cell Reports, 2018
SUMMARY Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The ...
Yumeng Wang, Xiaoyan Xu, Dejan Maglic, Michael T. Dill, K. Mojumdar, P. Ng, Kang Jin Jeong, Y. Tsang, D. Moreno, V. H. Bhavana, Xinxin Peng, Zhongqi Ge, Hu Chen, Jun Li, Zhongyuan Chen, Huiwen Zhang, Leng Han, Di Du, Chad J. Creighton, Gordon B. Mills, F. Camargo, Han Liang   +21 more
semanticscholar   +1 more source

Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer

Cell Stem Cell, 2020
SUMMARY While the Hippo transcriptional coactivator YAP is considered oncogenic in many tissues, its roles in intestinal homeostasis and colorectal cancer (CRC) remain controversial.
Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, R. Panero, Jatin Roper, F. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, R. Calogero, Ömer H. Yilmaz, J. Mao, F. Camargo   +13 more
semanticscholar   +1 more source

Potentials for development of rural tourism in Bački Petrovac municipality [PDF]

Ekonomika Poljoprivrede (1979), 2014
The main goal of this paper is to prove the assumption that in the municipality of Bački Petrovac there is a predisposition for the development of rural tourism, taking into consideration the existing Spatial plan of the municipality, its conception and ...
Pejanović Radovan, Demirović Dunja, Đorđević Jasmina, Radović Gordana   +3 more
doaj   +1 more source

Identification of Potential Prognostic Biomarkers for Breast Cancer Based on lncRNA‐TF‐Associated ceRNA Network and Functional Module

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Breast cancer leads to most of cancer deaths among women worldwide. Systematically analyzing the competing endogenous RNA (ceRNA) network and their functional modules may provide valuable insight into the pathogenesis of breast cancer. In this study, we constructed a lncRNA‐TF‐associated ceRNA network via combining all the significant lncRNA‐TF ceRNA ...
Xinrong Li, Junquan Zhu, Jian Qiu, David A. McClellan   +3 more
wiley   +1 more source

The Optimization Process for Seaside Operations at Medium-Sized Container Terminals with a Multi-Quay Layout

Journal of Marine Science and Engineering, 2020
The optimization of seaside operations at container terminals includes solving standard berth and crane allocation problems. The question arises about the efficiency of such optimizations in small and medium-sized container terminals, with different quay
Neven Grubisic, Tomislav Krljan, Livia Maglic   +2 more
doaj   +1 more source