Results 71 to 80 of about 728,274 (341)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Multi-solute solid solution behavior and its effect on the properties of magnesium alloys
Journal of Magnesium and Alloys, 2022 The low-density magnesium (Mg) alloys are attractive for the application in aerospace, transportation and other weight-saving-required fields. The mechanical properties and corrosion properties of Mg alloys are the key-property issues for the wide ...
Jun Wang +7 more
doaj
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Magnesium Implants: Prospects and Challenges
Materials, 2019 Owing to their suitable mechanical property and biocompatibility as well as the technological possibility of controlling their high corrosion rates, magnesium and its alloys have attracted significant attention as temporary bio-implants.
P. Chakraborty Banerjee +4 more
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Effect of impurity elements on the corrosion behavior of Mg-Al alloys: A first principles study
Journal of Materials Research and TechnologyMagnesium-aluminum (Mg-Al) alloys are promising lightweight materials but are prone to severe corrosion induced by trace impurities (Fe, Ni, Cu) even at ppm levels.
Tao Chen +6 more
doaj
The Role of Magnesium in Neurological Disorders
Nutrients, 2018 Magnesium is well known for its diverse actions within the human body. From a neurological standpoint, magnesium plays an essential role in nerve transmission and neuromuscular conduction.
Anna E. Kirkland +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Effect of Gd content on the microstructure, texture and mechanical properties of Mg-xGd-0.5Mn alloys
Journal of Materials Research and Technology, 2022 In this work, we investigated the microstructure and the mechanical properties of extruded Mg-xGd-0.5Mn alloys (GMx0) with the variation of Gd content (0, 2, 4, 7 wt.%).
Chao He +10 more
doaj
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source