Results 71 to 80 of about 319,237 (263)

Magnesium [PDF]

Advances in Nutrition, 2016
Rebecca, Costello, Taylor C, Wallace, Andrea, Rosanoff   +2 more
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Magnesium enhances soil carbon sequestration by modulating carbon-cycling microorganisms under reduced fertilisation conditions

Scientia Horticulturae
Soil organic carbon (SOC) depletion remains a central challenge for tea plantations under intensive fertilisation. We evaluated three fertilisation strategies including farmer fertilisation (FF), optimised fertilisation (OF), and optimised fertilisation ...
Hao Ji, Hongyu Yang, Zetian Zhang, Hao Wu, Zhiyi Liu, Liangquan Wu, Shanghuan Li, Xuechun Li, Huihuang Wu, Chengcong Chen, Fuhan Lv, Linying Wang, Yirong Lai, Wei Lin, Lijin Guo   +14 more
doaj   +1 more source

Substitution of Ni for Zn on microstructure and mechanical properties of Mg–Gd–Y–Zn–Mn alloy

Journal of Magnesium and Alloys, 2017
This study analyzes the effect of substitution of Ni for Zn on microstructure and mechanical properties of Mg–Gd–Y–Zn–Mn alloy. Our results show that the volume fraction of Mg5(Gd, Y) and (Mg, Zn)3RE phase decreased and LPSO phase increased with more ...
Rongqing Zhang, Jingfeng Wang, Song Huang, Shijie Liu, Fusheng Pan   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Preparation of the high mechanical and damping performance Mg-Y-Zn alloys with three Y/Zn ratios using the hot extrusion deformation process

Materials & Design
To develop magnesium alloys with both excellent mechanical and damping properties, three Mg–Y–Zn alloys with varying Y/Zn ratios (Mg95Y3Zn2, Mg95Y3.5Zn1.5, Mg95Y3.8Zn1.2 (at.%)) were innovatively designed based on an arithmetic progression ...
Baolin Chen, Yanhui Liu, Liangliang Xue, He Qin, Ming Liang, Feng Zhao, Jianfeng Li   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source