Results 51 to 60 of about 117,424 (361)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Weld microfissuring in Inconel 718 minimized by minor elements [PDF]

open access: yes, 1968
Manganese, silicon, and magnesium markedly reduce the tendency of Inconel 718 to weld microfissuring. By combining a manganese, 0.20 percent by content, with silicon, greater than 0.25 percent content, or by adding 20 ppm of magnesium, the weld ...
Morrison, T. J.   +2 more
core   +1 more source

In Vivo Corrosion of Two Novel Magnesium Alloys ZEK100 and AX30 and Their Mechanical Suitability as Biodegradable Implants [PDF]

open access: yes, 2011
In magnesium alloys, the components used modify the alloy properties. For magnesium implants in contact with bone, rare earths alloys are commonly examined.
Angrisani, Nina   +5 more
core   +3 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

The misalignment between degradation rate and mechanical integrity of Mg-Zn-Y-Nd alloy during the degradation evaluation in modified Hanks' solutions

open access: yesJournal of Magnesium and Alloys
The degradation behavior of biodegradable Mg alloys has become a research hotspot in the fields about biodegradable metallic materials. While the most of the related publications mainly focused on the degradation rate of Mg-based materials, but rare to ...
Di Mei   +9 more
doaj   +1 more source

Biocompatibility, Degradation Behavior, and Mechanical Properties of Magnesium Alloy Plates In Vivo

open access: yesApplied Bionics and Biomechanics, 2023
The magnesium alloy was made into orthopedic steel plates to repair tibial fractures of New Zealand white rabbits and to explore the biocompatibility, degradation behavior, and mechanical properties of the magnesium alloy plates in repairing fractures in
Yongping Wang   +6 more
doaj   +1 more source

Research Progress in Relation to Composite Brazing Materials with Flux

open access: yesCrystals, 2021
Brazing was one of the earliest material-joining methods to be invented and widely used by humans. In the past 30 years, the technology and materials employed for brazing have developed rapidly and continuously.
Bo Wang   +6 more
doaj   +1 more source

Autopassive Wrought Magnesium Alloys

open access: yesAdvanced Engineering Materials, 2001
Peer ...
Adeva, Paloma   +5 more
openaire   +3 more sources

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

open access: yesFEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita   +3 more
wiley   +1 more source

Magnesium Alloys for Implants [PDF]

open access: yesManufacturing Technology, 2013
Extraordinary properties of magnesium alloys, biodegrability and low density guarantee that these alloys are suitable for using in medicine as bone implants. So far there have been used alloys of titanium, cobalt and stainless steel for this purpose. Among the mentioned materials the magnesium alloys are winning because of their mechanical properties ...
Dalibor Vojtěch   +2 more
openaire   +2 more sources

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