Results 201 to 210 of about 1,288,376 (374)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

open access: yesAdvanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez   +5 more
wiley   +1 more source

Influence of Cooling Rate on Primary Silicon Size in Hypereutectic Al–Si Alloy Fabricated by Laser Powder Bed Fusion

open access: yesAdvanced Engineering Materials, EarlyView.
Al–Si alloys are particularly in demand for automotive and electronic applications, thanks to their excellent wear and thermal properties. Nevertheless, when processed by conventional methods with low cooling rates, the coarse primary Si phases are responsible for increasing brittleness and inducing crack propagation.
Layla Shams Tisha   +3 more
wiley   +1 more source

Intermetallic Compound Layer Morphology and Distribution in Friction‐Welded Steel–Aluminum Components

open access: yesAdvanced Engineering Materials, EarlyView.
In this study, how friction‐welding parameters (rotational speed, etc.) affect the morphology, distribution, and local thickness of the intermetallic compound layer (IMC‐layer) in friction‐welded steel‐aluminum hybrid components is investigated. In the results, it is shown that lower speeds (700 rpm) lead to a more uniform, thinner IMC‐layer (<0.5 μm),
Christoph Kahra   +6 more
wiley   +1 more source

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