Results 51 to 60 of about 1,387,552 (283)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Evaluation of micronutrients among pediatric liver cirrhosis in Shiraz, Iran

open access: yesEgyptian Liver Journal, 2022
Background Cirrhosis is the final result of most types of liver disease. Zinc, magnesium, and vitamin D have a significantly vital role in the immunologic and physiologic mechanisms in the body.
Seyed Mohsen Dehghani   +3 more
doaj   +1 more source

The relationship between magnesium deficiency and depression, and the effects of magnesium supplementation on depression symptoms – literature review

open access: yesJournal of Education, Health and Sport, 2022
Magnesium is a very important macronutrient in the human body. Its main storage is bones. The correct concentration of this macronutrient within the normal range is necessary for the proper functioning of the body.
Dominik Machaj   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The power of magnesium: unlocking the potential for increased yield, quality, and stress tolerance of horticultural crops

open access: yesFrontiers in Plant Science, 2023
Magnesium (Mg2+) is pivotal for the vitality, yield, and quality of horticultural crops. Central to plant physiology, Mg2+ powers photosynthesis as an integral component of chlorophyll, bolstering growth and biomass accumulation.
N. Ahmed   +9 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The role of magnesium in the treatment of symptoms climacteric syndrome

open access: yesМедицинский совет, 2019
According to epidemiological studies, about 30% of residents in Russia receive less than 70% of the daily magnesium intake, while magnesium deficiency manifests much more often in women than in men.
A. Z. Khashukoeva   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

open access: yesMolecules, 2021
Magnesium (Mg2+) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease.
Derek R. Case   +3 more
doaj   +1 more source

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