Results 51 to 60 of about 93,126 (269)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Ethical Values and Biological Diversity: A Preliminary Assessment Approach

Journal of Microbiology & Biology Education, 2014
There have been five major extinction events over geological time. However, the current rate of extinction or reduction of species and their habitats is directly related to anthropomorphic causes.
Joel I. Cohen
doaj   +1 more source

Magnetic Pumps [PDF]

, 2013
Micropumps can be classified into two general categories: mechanical and nonmechanical micropumps (an excellent review on micropumps can be found elsewhere [1]). In a typical mechanical pump, a membrane is used to produce the pumping action. Nonmechanical micropumps on the other hand generally have no moving parts.
Çetin, Barbaros, Zeinali, Soheila, Li, D.   +2 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Jappe, Anselm; Maiso, Jordi; Rojo, José Manuel: Criticar el valor, superar el capitalismo.

Oxímora. Revista Internacional de Ética y Política, 2015
La agudización de la crisis del capitalismo a la que estamos asistiendo -por lo menos de forma nítida desde el año 2008- ha favorecido la difusión internacional de los planteamientos de los teóricos del valor.
Jordi Magnet Colomer
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Transport phase diagram and anomalous metallicity in superconducting infinite-layer nickelates

Nature Communications
Despite obvious similarities in their electronic and crystallographic structures, it remains unclear whether the interactions that shape the normal and superconducting (SC) state properties of high-T c cuprates and infinite-layer nickelates (ILNs) have ...
Yu-Te Hsu, Kyuho Lee, Sven Badoux, Caitlin Duffy, Alessandro Cuoghi, Bai Yang Wang, Arwin Kool, Isaac Haïk-Dunn, Harold Y. Hwang, Nigel E. Hussey   +9 more
doaj   +1 more source

¿Una crítica inmanente radical? Entrevista a José Manuel Romero Cuevas

Oxímora. Revista Internacional de Ética y Política, 2016
José Manuel Romero Cuevas (Sanlúcar de Barrameda, 1970) es profesor en la Universidad de Alcalá (Madrid). Se doctoró en la Universidad de Granada (UGR) con una tesis sobre el problema del conocimiento en F.
Jordi Magnet Colomer
doaj   +1 more source