Results 141 to 150 of about 11,654,333 (303)

Bcl-xL regulates radiation-induced ferroptosis through chaperone-mediated autophagy of GPX4 in tumor cells

Radiation Medicine and Protection
Objective: To investigate the role and the molecular mechanisms of apoptotic signaling in ferroptosis to regulate tumor radiosensitivity. Methods: Reactive oxygen species (ROS) and lipid peroxide levels were detected in Mouse embryonic fibroblasts(MEFs ...
Jing Han, Ruru Wang, Bin Chen, Feng Xu, Liangchen Wei, An Xu, Lijun Wu, Guoping Zhao   +7 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Magnetic feedback control of a Field Reversed Configuration

Nuclear Fusion
The Field Reversed Configuration (FRC) is a highly diamagnetic plasma confinement device used in nuclear fusion research. FRC’s exhibit an internal region of weak magnetic field with ideal conditions to reach the high temperature required to burn high Z ...
J.A. Romero, K. Phung, S. Galkin, S. Putvinski, G. Snitchler, D. Madura, D. Otagiri, R. Sterbenz, T. Roche, J.B. Titus, E. Trask, S. Dettrick, the TAE Team   +12 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Demonstration of reconstruction-free static magnetic control of DIII-D plasma with deep reinforcement learning

Nuclear Fusion
This paper presents the development and experimental validation of a reinforcement learning (RL)-based magnetic controller on the DIII-D tokamak. The controller directly maps raw magnetic diagnostic signals to actuator commands, replacing the traditional
G.F. Subbotin, D.I. Sorokin, M.R. Nurgaliev, A.A. Granovskiy, I.P. Kharitonov, E.V. Adishchev, E.N. Khairutdinov, R. Clark, H. Shen, W. Choi, J. Barr, D.M. Orlov   +11 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Action control in uncertain environments [PDF]

, 2015
A long-standing dichotomy in neuroscience pits automatic or reflexive drivers of behaviour against deliberate or reflective processes. In this thesis I explore how this concept applies to two stages of action control: decision-making and response ...
Smittenaar, P
core  

A Novel Milli‐Scale Magnetic Robot Exploiting Rotation for Controlled Magnetic Particles Release

Advanced Intelligent Systems
Delivering magnetic particles to specific sites in the body offers a minimally invasive approach to drug administration, enabling precise therapeutic control and reducing systemic exposure.
Giordano De Angelis, Tamerlan Srymbetov, Arianna Menciassi, Veronica Iacovacci   +3 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

PWM Control of a Buck Converter with an Amorphous Core Coil [PDF]

, 2011
Pulse-width modulation is widely used to control electronic converters. One of the most topologies used for high DC voltage/low DC voltage conversion is the Buck converter.
Morón Fernández, Carlos, Morales Cabrera, Rafael, Somolinos Sánchez, José Andrés, García García, Alfonso   +3 more
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