Results 51 to 60 of about 222,259 (265)

Magnetic Integration Applied to an Isolated Single-Stage AC–DC Converter

IEEE Open Journal of Power Electronics
This work proposes a novel magnetic integration approach applied to a four-leg interleaved single-phase ac-dc converter topology, aimed at minimizing component count and increasing power density.
Samanta Gadelha Barbosa, Jose Willamy Medeiros de Araujo, Jens Friebe, Fernando Lessa Tofoli, Demercil de Souza Oliveira   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Machine Learning-Based Magnetocardiography Model Aids in Diagnosing Non-ST-Segment Elevation Acute Coronary Syndrome in Acute Chest Pain

Balkan Medical Journal
Background: Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is a leading cause of acute chest pain in clinical practice. Magnetocardiography (MCG) is a non-invasive and rapid functional imaging technique with high sensitivity to early, subtle
Junting Li, Yuheng Zhou, Ruizhe Wang, Jiaojiao Pang, Min Xiang, Xiaolin Ning   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effects of scanning strategy on the magnetic and mechanical properties of laser-based powder bed fused Nd-Fe-B magnets

Journal of Materials Research and Technology
In the past decades, laser-based powder bed fusion (LPBF) has been well-established for near-net-shape forming Nd-Fe-B magnets, efficiently employing the rare-earth elements (REE) and exhibiting the potential for directly fabricating magnets with complex
Xin Ming, Xu Han, Jiantao Zhou, Jiefu Xiong, Lichen Wang, Dan Liu, Baogen Shen   +6 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer’s Disease Biomarkers at the Zeptomole Level

Research
Due to the low concentration of amyloid-beta (Aβ) in plasma and the high content of interfering factors, the conventional detection method for the quantification of Aβ still faces the problem of insufficient limit of detection (LOD).
Huide Wang, Meng Qiu, Chen Wang, Liding Zhang, Ning Fan, Zhi Chen, Yi Liu, Tianzhong Li, Ziqian Wang, Yihan Zhu, Yule Zhang, Xilin Tian, Yun Wang, Mingmin Yang, Dianyuan Fan, Qingming Luo, Ke Jiang, Haiming Luo, Han Zhang   +18 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source