Results 71 to 80 of about 219,983 (266)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Immunomodulation of Patients with Canine Visceral Leishmaniasis at Different Stages: A 12-Month Follow-Up Study Using LaSap

Vaccines
Background/Objectives: Canine visceral leishmaniasis (CVL) is one of the main neglected protozoan diseases in the world. Dogs play a fundamental role in the maintenance of Leishmania infantum in the Americas, and we have already encountered resistance ...
Kelvinson Fernandes Viana, Adrieli Barboza de Souza, Sara Torres, Maria Camila Escobar Garcia, Açucena Veleh Rivas, Alex Sander Rodrigues Cangussu, Francisca Hildemagna Guedes da Silva, Rodolfo Cordeiro Giunchetti   +7 more
doaj   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Source imaging method based on diagonal covariance bases and its applications to OPM-MEG

NeuroImage
Magnetoencephalography (MEG) is a noninvasive imaging technique used in neuroscience and clinical research. The source estimation of MEG involves solving a highly underdetermined inverse problem, which requires additional constraints to restrict the ...
Wen Li, Fuzhi Cao, Nan An, Wenli Wang, Chunhui Wang, Weinan Xu, Dexin Yu, Min Xiang, Xiaolin Ning   +8 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR

Communications Chemistry
Non-specific disruption of cellular membranes induced by amyloidogenic aggregation of β-amyloid (Aβ) peptides remains a viable cytotoxicity mechanism in Alzheimer’s disease (AD).
Maurine K. Kengwerere, June M. Kenyaga, Peng Xiao, Shubha S. Gunaga, Faith J. Scott, Xyomara Wutoh-Hughes, James Wang, Brian Lum, Yan Sun, Frederic Mentink-Vigier, Tuo Wang, Wei Qiang   +11 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Artificial intelligence driven Mid-IR photoimaging device based on van der Waals heterojunctions of black phosphorus

Nanophotonics
Mid-infrared (Mid-IR) photodetection and imaging are pivotal across diverse applications, including remote sensing, communication, and spectral analysis.
Wang Ziqian, Wang Huide, Wang Chen, Bao Yushuo, Zheng Weiying, Weng Xiaoliang, Zhu Yihan, Liu Yi, Zhang Yule, Tian Xilin, Sun Shuo, Cao Rui, Shi Zhe, Chen Xing, Qiu Meng, Wang Hao, Liu Jun, Chen Shuqing, Zeng Yu-Jia, Liao Wugang, Huang Zhangcheng, Li Haiou, Gao Lingfeng, Li Jianqing, Fan Dianyuan, Zhang Han   +25 more
doaj   +1 more source

Optimizing DC-DC Converters through Interleaved Parallel Magnetic Integration: A Research Review

International Journal of Electrical, Energy and Power System Engineering
One of the main areas of focus for power electronics development nowadays is interleaved parallel magnetic integration technology. On the basis of introducing the staggered parallel connection technology of internal combustion engines and power systems ...
Muhammad Qasim Nawaz, Aimal Khan Khan
doaj   +1 more source

Numerical study on the effect of the magnetic field generated by circular coils with rectangular sections on plasma characteristics in low-pressure capacitive RF argon discharges [PDF]

AIP Advances
Based on electromagnetic theory, a model of the magnetic field generated by three circular coils with a rectangular cross-section was developed. The magnetic vector potential is computed using three-dimensional composite Simpson integration, and the ...
Yonghao Xu, Haoyu Gao, Feng Shi
doaj   +1 more source