Results 51 to 60 of about 7,536,747 (258)

Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer’s Disease Biomarkers at the Zeptomole Level

Research
Due to the low concentration of amyloid-beta (Aβ) in plasma and the high content of interfering factors, the conventional detection method for the quantification of Aβ still faces the problem of insufficient limit of detection (LOD).
Huide Wang, Meng Qiu, Chen Wang, Liding Zhang, Ning Fan, Zhi Chen, Yi Liu, Tianzhong Li, Ziqian Wang, Yihan Zhu, Yule Zhang, Xilin Tian, Yun Wang, Mingmin Yang, Dianyuan Fan, Qingming Luo, Ke Jiang, Haiming Luo, Han Zhang   +18 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Comparative evaluation of a deep learning method QNet and LCModel for MRS quantification on the cloud computing platform CloudBrain-MRS

BMC Medical Imaging
Objectives Reliable magnetic resonance (MR) spectroscopy (MRS) quantification is key to accurate clinical diagnosis. This study aimed to statistically compare the metabolite quantification of human brain MRS between the deep learning method QNet and the ...
Meijin Lin, Lin Guo, Dicheng Chen, Jianshu Chen, Zhangren Tu, Xu Huang, Jianhua Wang, Ji Qi, Yuan Long, Zhiguo Huang, Di Guo, Xiaobo Qu, Haiwei Han   +12 more
doaj   +1 more source

Formability and mechanism of ultra-thin titanium foil under the elevated temperature and high strain rate in electromagnetic forming

Journal of Materials Research and Technology
Electromagnetic forming (EMF) is a high-speed forming process with significant potential for manufacturing bipolar plates. However, titanium's low conductivity requires the use of a driver sheet in traditional EMF, limiting its formability improvement ...
Zelin Wu, Pengxin Dong, Yifan Huang, Yao Chen, Runze Liu, Quanliang Cao, Liang Li, Hao Wang, Xiaotao Han, Qiuliang Wang   +9 more
doaj   +1 more source

Beyond correlation: functional OPTO-MAgnetic Integration Concept (OPTOMAIC) to reveal the brain-wide signature of local neuronal signals-of-interest. [PDF]

Neurophotonics, 2022
Cleppien D, Aedo-Jury F, Stroh A.
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Expanding the clinical application of OPM-MEG using an effective automatic suppression method for the dental brace metal artifact

NeuroImage
Optically pumped magnetometer magnetoencephalography (OPM-MEG) holds significant promise for clinical functional brain imaging due to its superior spatiotemporal resolution.
Ruonan Wang, Kaiwen Fu, Ruochen Zhao, Dawei Wang, Zhimin Yang, Wei Bin, Yang Gao, Xiaolin Ning   +7 more
doaj   +1 more source