Results 61 to 70 of about 766,392 (293)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Lightweight, High-Efficiency, High-Dynamic-Response and Low-Ripple DC-DC Converters Based on Interleaved Magnetic Integrated Switched-Coupled Inductor for Electric Propulsion Aircraft

Aerospace
With the development of distributed electric propulsion aircraft, researching airborne high-efficiency, high-power-density, high-gain, high-dynamic and low-ripple, low-stress DC-DC that meets aviation standards is an urgent and profoundly challenging ...
Rui Guo, Hongkai Gao, Li Chen, Yiyi Zhang, Lei Wang   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Upper limits to the magnetic field in central stars of planetary nebulae

, 2014
More than about twenty central stars of planetary nebulae (CSPN) have been observed spectropolarimetrically, yet no clear, unambiguous signal of the presence of a magnetic field in these objects has been found.
Corradi, R. L. M., Gonzalez, M. J. Martinez, Leone, F., Ramos, A. Asensio, Sainz, R. Manso   +4 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Magnetic Integrated Multi-Trap Filters Using Mutual Inductance to Mitigate Current Harmonics in Grid-Connected Power Electronics Converters

Energies
This paper introduces magnetic integrated high-order trap–trap–inductor (TTL) and inductor–trap–trap (LTT) filters featuring two LC-traps designed for grid-tied inverters, aimed at reducing the size of output-power multi-trap filters.
Maged Al-Barashi, Aicheng Zou, Yongjun Wang, Wei Luo, Nan Shao, Zeyu Tang, Bing Lu   +6 more
doaj   +1 more source

Primordial magnetic fields and the HI signal from the epoch of reionization

, 2009
The implication of primordial magnetic-field-induced structure formation for the HI signal from the epoch of reionization is studied. Using semi-analytic models, we compute both the density and ionization inhomogeneities in this scenario.
C. Caprini, D. Paoletti, D. Scott, D.R.G. Schleicher, HST collaboration, J.D. Bowman, Kandaswamy Subramanian, M. Zaldarriaga, N.Y. Gnedin, P. Madau, R. Barkana, R. Barkana, R.H. Becker ., R.L. White, S. Furlanetto, S.G. Djorgovski, S.K. Sethi, Shiv K Sethi, WMAP collaboration, X. Fan, Z. Haiman, Z. Haiman, Z. Haiman   +22 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A Novel Magnetic Integration High-Efficiency Converter with Low Ripple and High Dynamic Response for the Hybrid Power Supply Systems of All-Electric Aircraft

Aerospace
With the continuous improvement of battery energy density and converter power density, as well as the miniaturization and lightweighting of related airborne electrical equipment, all-electric aircraft with hybrid power supply systems provide more trade ...
Li Chen, Haifeng Gao, Fengjie Shen, Yiyi Zhang, Liangjie Qiu, Lei Wang   +5 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source