Results 141 to 150 of about 11,255,110 (351)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Towards Standardized Magnetic Components Under Power Electronics Excitation With User-Friendly Loss Maps

IEEE Open Journal of Power Electronics
Nowadays, in a power electronics system, most components such as power electronics devices (MOSFETs, IGBTs, etc.) and capacitors are standardized, i.e., sold as a whole standard item with various values and ratings.
Navid Rasekh, Jun Wang, Xibo Yuan
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Analysis of effects of magnetic slot wedges on characteristics of large induction motor

, 2012
Magnetic slot wedges are often used to improve starting performance of large induction motors. In this paper we have investigated – through simulation – the effects of the wedges on the performance characteristics of the motor and core losses under no ...
Dems, M., Komeza, K., Sykulski, J.K.
core  

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Achieving Ultra-Broad Microwave Absorption Bandwidth Around Millimeter-Wave Atmospheric Window Through an Intentional Manipulation on Multi-Magnetic Resonance Behavior

Nano-Micro Letters
The frequency and intensity of multi-magnetic resonance are freely regulated by co-doping La3+ and Zr4+ ions. Zr4+ occupation is elaborately modified for promoting the portion of polarization/conduction loss to increase profoundly.
Chuyang Liu, Lu Xu, Xueyu Xiang, Yujing Zhang, Li Zhou, B. Ouyang, Fan Wu, Dong‐Hyun Kim, Guangbin Ji   +8 more
semanticscholar   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Loss Cone Region in Toroidal Helical Systems [PDF]

, 1990
Analytic formula is derived for the loss cone in the toroidal helical systems. Particular emphasis is put on the loss region for the particles which are barely trapped in the helical ripples.
Hanatani, K., Sanuki, H., Itoh, S.-I., Itoh, K., Fukuyama, A., Kamimura, T., Todoroki, J.   +6 more
core  

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.
Francesco Fortunato, Alessia Giugno, Miriam Sturniolo, Enrico Fratto, Pio Zoleo, Francesca Felicia Operto, Ilaria Sammarra, Antonio Gambardella   +7 more
wiley   +1 more source

Effects of Magnetic Powder Filling Ratio on the Characteristics of a Magnetic Composite Core Motor

IEEE Access
Magnetic-composite materials, comprising soft magnetic powder and a resin binder, are characterized by excellent machinability and low iron loss. Motors with stator cores made of magnetic-composite materials (magnetic composite core (MCC) motors) can ...
Takashi Nakamura, Ren Washioka, Kenichiro Ochiai, Tsutomu Mizuno, Mitsuhide Sato   +4 more
doaj   +1 more source