Results 81 to 90 of about 7,856,512 (343)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Powerful Winds from Low-Mass Stars: V374 Peg [PDF]

, 2011
The rapid rotation (P=0.44 d) of the M dwarf V374Peg (M4) along with its intense magnetic field point toward magneto-centrifugal acceleration of a coronal wind.
A. A. Vidotto, Badalyan, Belcher, Berger, Berger, Catalán, Collier Cameron, Connerney, Delfosse, Donati, Donati, Giampapa, Güdel, Hartman, Herczeg, Irwin, Irwin, J. F. Donati, Jardine, Kasting, Keppens, Keppens, Lim, Lim, Low, M. Jardine, M. Opher, Matt, Meibom, Mestel, Mestel, Michel, Mohanty, Morin, Morin, Morin, Mullan, Ness, Ness, Opher, Parker, Plavchan, Pneuman, Powell, Riley, Scalo, Schmitt, Scholz, Skumanich, T. I. Gombosi, Tóth, Ud-Doula, van den Oord, Vidotto, Vidotto, Vidotto, Wargelin, Wargelin, Weber, West, Wood, Zendejas   +61 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Orbital hybridization and charge distribution modulation in MOF-derived carbon materials for tailored electromagnetic attenuation

Journal of Advanced Ceramics
Despite the extensive research conducted on dielectric–magnetic coupling in metal-organic frameworks (MOF)-derived absorbers, the underlying mechanisms associated with defects, interfaces, and orbital hybridization remain inadequately investigated.
Yuan Liu, Muhe Li, Rong Li, Yuchang Qing, Long Wang, Bingbing Fan   +5 more
doaj   +1 more source

Increasing the efficiency of a drone motor by arranging magnetic sheets to windings

Energy Reports, 2020
In recent years, there has been an increase in motorization; therefore, the demand for high-efficiency motors in automobiles and aircrafts will further increase.
Mitsuhide Sato, Masami Nirei, Yuichiro Yamanaka, Tatsuki Suzuki, Yinggang Bu, Tsutomu Mizuno   +5 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Alternating current losses in superconducting coils [PDF]

, 1972
Report examines relationship between coil loss and frequency and heat loss in coil as a function of the magnetic field H.
Guderjahn, C. A., Wipf, S. L.
core   +1 more source

Star-planet magnetic interaction and evaporation of planetary atmospheres

, 2013
Stars interact with their close-in planets through radiation, gravitation, and magnetic fields. We investigate the energy input to a planetary atmosphere by reconnection between stellar and planetary magnetic fields and compare it to the energy input of ...
Lanza, A. F.
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source