Results 31 to 40 of about 238 (199)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Mirrorless open cavities enabled by boundary incompatibility between perfect electric conductor and perfect magnetic conductor parallel-plate waveguides

open access: yesScientific Reports
The most basic approach to confining electromagnetic waves is to place mirrors along their path, yet achieving confinement without conventional mirrors remains a major challenge.
Seong-Han Kim, Chul-Sik Kee
doaj   +1 more source

INTEGRAL EQUATIONS FOR MODELING CYLINDRICAL MIRROR ANTENNAS

open access: yesРоссийский технологический журнал, 2017
The application of integral equations of magnetic field strength for simulating the radiation of multi-mirror antennas with cylindrical reflectors is considered in the article.
V. I. Nefedov   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Realization of a Single-Layer Terahertz Magnetic Mirror [PDF]

open access: yesIEEE Access, 2020
We experimentally demonstrate a single-layer terahertz dielectric metasurface. The metasurface consists of an array of sub-wavelength fibers. It is shown that this single-layer terahertz metasurface has high transmission window and can also behave like a terahertz magnetic or electric mirror due to the excitation of resonances in the fibers. It is also
Qigejian Wang   +3 more
openaire   +3 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Transmission and Reflection Spectra of a Bragg Microcavity Filled with a Periodic Graphene-Containing Structure

open access: yesApplied Sciences, 2023
The transmission and reflection spectra of a one-dimensional microresonator structure with dielectric Bragg mirrors, the working cavity of which is filled with several “dielectric-graphene” or “semiconductor-graphene” periods with controlled material ...
Irina V. Fedorova   +2 more
doaj   +1 more source

The Axisymmetric Tandem Mirror: A Magnetic Mirror Concept Game Changer Magnet Mirror Status Study Group

open access: yes, 2008
Experimental results, theory and innovative ideas now point with increased confidence to the possibility of a Gas Dynamic Trap (GDT) neutron source which would be on the path to an attractively simple Axisymmetric Tandem Mirror (ATM) power plant. Although magnetic mirror research was terminated in the US 20 years ago, experiments continued in Japan ...
T Simonen   +23 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy