Results 41 to 50 of about 4,024,090 (252)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Reducing displacement artifacts by warping system matrices in efficient joint multi-patch magnetic particle imaging

, 2020
The reconstruction of multi-patch magnetic particle imaging data requires a compromise between image quality and calibration time. While optimal image quality is ensured by the joint reconstruction approach, a system matrix needs to be acquired for each ...
Möddel, Martin, Knopp, Tobias, Boberg, Marija   +2 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Magnetic-field measurement and simulation of a field-free line magnetic-particle scanner

Current Directions in Biomedical Engineering, 2017
In 2005, B. Gleich and J. Weizenecker initially presented the tracer based medical imaging modality Magnetic Particle Imaging (MPI). It uses the nonlinear magnetization behavior of super paramagnetic iron oxide nanoparticles (SPIONs).
Stelzner Jan, Buzug Thorsten M.
doaj   +1 more source

Superferromagnetic Disk Particles for Magnetic Particle Imaging

Small Methods
Abstract Magnetic particle imaging (MPI) offers rapid, highly sensitive tracer‐based imaging without ionizing radiation, but its clinical translation remains challenged by the limited performance of existing superparamagnetic (SP) tracers. In this work, precisely engineered disk‐shaped nanoparticles fabricated from superferromagnetic (
Erik M. Mayr, Justin Ackers, Alexander Gogos, Subas Scheibler, Michal Krupinski, Matthias Graeser, Inge K. Herrmann, Hans J. Hug   +7 more
openaire   +4 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Molecular Imaging, 2023
Magnetic particle imaging (MPI) is a new tracer-based imaging modality that is useful in diagnosing various pathophysiology related to the vascular system and for sensitive tracking of cytotherapies.
Prashant Chandrasekharan, Renesmee Kuo, K. L. Barry Fung, Chinmoy Saayujya, Jacob Bryan, Mariam Yousuf, Benjamin Fellows, Caylin Colson, Quincy Huynh, Owen Doyle, Allison Hartley, Khadija Yousuf, Patrick Goodwill, Steven Conolly   +13 more
doaj   +1 more source