Results 91 to 100 of about 382,379 (299)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Advanced ScienceFlexible electronic devices extended abilities of humans to perceive their environment conveniently and comfortably. Among them, flexible magnetic field sensors are crucial to detect changes in the external magnetic field.
Shengbin Li +14 more
doaj +1 more source
Sensors, 2016 Multiferroic composites with ferromagnetic and ferroelectric phases have been studied in recent years for use as sensors of AC and DC magnetic fields. Their operation is based on magneto-electric (ME) coupling between the electric and magnetic subsystems
Gollapudi Sreenivasulu +4 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Hybrid manganite-graphene sensor for magnetic field magnitude and direction measurement
Scientific ReportsIn this work, we present a novel hybrid magnetic sensor that combines the unique properties of manganite and graphene to measure both the magnitude and direction of a magnetic field.
Nerija Žurauskienė +10 more
doaj +1 more source
Magnetic-Particle-Sensing Based Diagnostic Protocols and Applications
Sensors, 2015 Magnetic particle-labeled biomaterial detection has attracted much attention in recent years for a number of reasons; easy manipulation by external magnetic fields, easy functionalization of the surface, and large surface-to-volume ratio, to name but a ...
Tsukasa Takamura +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
IEEE Open Journal of Circuits and SystemsThis work presents a small-area 2nd-order continuous-time $\Delta \Sigma $ Modulator (CT $\Delta \Sigma \text{M}$ ) with a single low dropout regulator (LDO) serving as both the power supply for the CT $\Delta \Sigma \text{M}$ and reference voltage ...
Manish Srivastava +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source