Results 71 to 80 of about 382,379 (299)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Quantitative nanoscale vortex-imaging using a cryogenic quantum magnetometer [PDF]

, 2015
Microscopic studies of superconductors and their vortices play a pivotal role in our understanding of the mechanisms underlying superconductivity. Local measurements of penetration depths or magnetic stray-fields enable access to fundamental aspects of ...
A Dréau, AF Young, B. Müller, CG Yale, D Vasyukov, D. Koelle, D. Rohner, E Schaefer-Nolte, E. Neu, F Tafuri, G Balasubramanian, G Balasubramanian, G Carneiro, G De Lange, HF Hess, J Pearl, J Taylor, J Xia, JE Hoffman, JP Tetienne, JR Kirtley, L Embon, L Luan, L Robledo, L Rondin, L Rondin, L. Thiel, LS Bouchard, M. Ganzhorn, O Fischer, OM Auslaender, P Appel, P Maletinsky, P. Appel, P. Maletinsky, R Werner, R Wölbing, R. Kleiner, S Kolkowitz, S Scharinger, SJ Bending, T Timusk, U Essmann, VZ Kresin, WN Hardy   +44 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Electrical Characterization of Gold-DNA-Gold Structures in Presence of an External Magnetic Field by Means of I-V Curve Analysis

Sensors, 2012
This work presents an experimental study of gold-DNA-gold structures in the presence and absence of external magnetic fields with strengths less than 1,200.00 mT. The DNA strands, extracted by standard method were used to fabricate a Metal-DNA-Metal (MDM)
Wan Haliza Abd Majid, Richard Ritikos, Nadia Mahmoudi Khatir, Vengadesh Periasamy, Seyedeh Maryam Banihashemian, Saadah Abdul Rahman   +5 more
doaj   +1 more source

Local magnetic measurements in magnetic circuits with highly nonuniform electromagnetic fields [PDF]

, 2009
In this paper, local magnetic measurements are carried out in magnetic circuits with highly non uniform electromagnetic field patterns, including excitation winding and/or air gaps, as in the case of rotating electrical machines.
Dupré, Luc, Mohamed Abouelyazied Abdallh, Ahmed   +1 more
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Fabrication and Characterization of CMOS-MEMS Magnetic Microsensors

Sensors, 2013
This study investigates the design and fabrication of magnetic microsensors using the commercial 0.35 μm complementary metal oxide semiconductor (CMOS) process.
Ming-Zhi Yang, Ching-Liang Dai, Chen-Hsuan Hsieh   +2 more
doaj   +1 more source

High-sensitivity diamond magnetometer with nanoscale resolution

, 2008
We present a novel approach to the detection of weak magnetic fields that takes advantage of recently developed techniques for the coherent control of solid-state electron spin quantum bits.
A. Yacoby, AM Chang, AM Rey, BM Chernobrod, C Veauvy, CA Meriles, CL Degen, CP Slichter, D Budker, D Budker, D. Budker, DE Chang, E van Oort, F Jelezko, F Jelezko, FT Charnock, GR Khutsishvili, H Seton, HJ Mamin, HJ Mamin, IM Savukov, J Meijer, J. M. Taylor, JF Prins, JR Rabeau, K Khodjasteh, K Kominis, K Schlenga, KF Zhao, KM Salikhov, L Childress, L Viola, L. Childress, L. Jiang, M Auzinsh, M Mehring, M Vengalattore, M. D. Lukin, MVG Dutt, NB Manson, P Mansfield, P. Cappellaro, P. R. Hemmer, R Hanson, R Hanson, R. Walsworth, RJ Epstein, S Kühn, S Meiboom, SJ Bending, SK Sekatskii, T Gaebel   +51 more
core   +1 more source

Resolving single molecule structures with Nitrogen-vacancy centers in diamond. [PDF]

, 2015
We present theoretical proposals for two-dimensional nuclear magnetic resonance spectroscopy protocols based on Nitrogen-vacancy (NV) centers in diamond that are strongly coupled to the target nuclei.
Cai, J, Kost, M, Plenio, MB
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source