Results 91 to 100 of about 166,004,902 (280)

Nonparametric identification using instrumental variables: sufficient conditions for completeness [PDF]

This paper provides sufficient conditions for the nonparametric identification of the regression function m(.) in a regression model with an endogenous regressor x and an instrumental variable z.
Yingyao Hu, Ji-Liang Shiu
core  

Russell's Completeness Proof

, 2008
Bertrand Russell’s 1906 article ‘The Theory of Implication’ contains an algebraic weak completeness proof for classical propositional logic. Russell did not present it as such.
Milne, Peter
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The completeness of chest X-ray procedure codes in the Danish National Patient Registry [PDF]

, 2017
Peter Hjertholm,1 Kaare Rud Flarup,1 Louise Mahncke Guldbrandt,1 Peter Vedsted1,2 1Research Center for Cancer Diagnosis in Primary Care, Department of Public Health, 2University Clinic for Innovative Health Care Delivery, Diagnostic Centre, Silkeborg ...
Peter Hjertholm, Louise Mahncke Guldbrandt, Hjertholm P, Vedsted P, Kaare Rud Flarup, Flarup KR, Peter Vedsted, Guldbrandt LM   +7 more
core   +1 more source

The DECam Ecliptic Exploration Project (DEEP). III. Survey Characterization and Simulation Methods

The Astronomical Journal
We present a detailed study of the observational biases of the DECam Ecliptic Exploration Project’s B1 data release and survey simulation software that enables direct statistical comparisons between models and our data.
Pedro H. Bernardinelli, Hayden Smotherman, Zachary Langford, Stephen K. N. Portillo, Andrew J. Connolly, J. Bryce Kalmbach, Steven Stetzler, Mario Jurić, William J. Oldroyd, Hsing Wen Lin, Fred C. Adams, Colin Orion Chandler, Cesar Fuentes, David W. Gerdes, Matthew J. Holman, Larissa Markwardt, Andrew McNeill, Michael Mommert, Kevin J. Napier, Matthew J. Payne, Darin Ragozzine, Andrew S. Rivkin, Hilke Schlichting, Scott S. Sheppard, Ryder Strauss, David E. Trilling, Chadwick A. Trujillo   +26 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Assessment of seismicity using local broadband seismic network: a case study from Kashmir valley, NW, Himalaya, India

Geoenvironmental Disasters
Background The Kashmir Valley, situated within the northwest segment of the Himalayan orogen, representsa seismotectonically active intramontane basin.
Bikram Singh Bali, Nayeem Ahmad Bhat, Ahsan Afzal Wani, Sareer Ahmad Mir, Naseer Ahmad Bhat   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source