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Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

open access: yesAdvanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait   +7 more
wiley   +1 more source

Emergent metabolic parasitism driven by organelle sequestration. [PDF]

open access: yesSci Adv
Moeller HV   +7 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun   +7 more
wiley   +1 more source

Effects of chemical preconditioning on organic acid production from woody biomass. [PDF]

open access: yesFront Chem
Gunukula S   +8 more
europepmc   +1 more source
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Completeness magnitude (Mc) and b-value characteristics as important parameters for future seismic hazard assessment in the West Papua province Indonesia

Arabian Journal of Geosciences, 2021
West Papua province in eastern Indonesia is located in a complex tectonic setting due to the convergence of the Australian, Pacific, and Eurasian plates. The interaction resulted in several major strike-slip faults, including Koor, Sorong, Ransiki, and Yapen, which are the main seismic routes in the study area.
Richard Lewerissa
exaly   +2 more sources

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