Results 41 to 50 of about 1,059,047 (247)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The influence of math anxiety on symbolic and non-symbolic magnitude processing

open access: yesFrontiers in Psychology, 2015
Deficits in basic numerical abilities have been investigated repeatedly as potential risk factors of math anxiety. Previous research suggested that also a deficient approximate number system (ANS), which is discussed as being the foundation for later ...
Julia Felicitas Dietrich   +7 more
doaj   +1 more source

Load Magnitude and Locomotion Pattern Alter Locomotor System Function in Healthy Young Adult Women

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
IntroductionDuring cyclical steady state ambulation, such as walking, variability in stride intervals can indicate the state of the system. In order to define locomotor system function, observed variability in motor patterns, stride regulation and gait ...
Kellen T. Krajewski   +10 more
doaj   +1 more source

Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases

open access: yesFluids and Barriers of the CNS, 2021
Background Several central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by phase-contrast magnetic resonance imaging (MRI). This technique is, however, limited
Per Kristian Eide   +4 more
doaj   +1 more source

Accounting for Natural Uncertainty Within Monitoring Systems for Induced Seismicity Based on Earthquake Magnitudes

open access: yesFrontiers in Earth Science, 2021
To reduce the probability of future large earthquakes, traffic light systems (TLSs) define appropriate reactions to observed induced seismicity depending on each event's range of local earthquake magnitude (ML).
Corinna Roy   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Pain magnitude at the preferential “gateway” of the Single Health System

open access: yesRevista Dor
BACKGROUND AND OBJECTIVES: Since the dawn of civilization, pain was and still is a major concern for humankind. It is estimated that 80% of the world population look for the health system due to pain complaints. American epidemiological studies show that
Simone Regina Alves de Freitas Barros   +2 more
doaj   +1 more source

Development of magnitude processing in children with developmental dyscalculia: Space, time and number

open access: yesFrontiers in Psychology, 2014
Developmental dyscalculia (DD) is a learning disorder associated with impairments in a preverbal non-symbolic approximate number system (ANS) pertaining to areas in and around the intraparietal sulcus (IPS).
Kenny eSkagerlund, Ulf eTräff
doaj   +1 more source

Developing a Fuzzy Inference System Based on Multi-Sensor Data to Predict Powerful Earthquake Parameters

open access: yesRemote Sensing, 2022
Predicting the parameters of upcoming earthquakes has always been one of the most challenging topics in studies related to earthquake precursors. Increasing the number of sensors and satellites and consequently incrementing the number of observable ...
Mehdi Akhoondzadeh, Dedalo Marchetti
doaj   +1 more source

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