Results 71 to 80 of about 232,137 (308)

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Aerodynamic Optimization Design of an Orthogonal Octo-Rotor UAV in a Hovering State

Drones
This paper presents a novel orthogonal octo-rotor Unmanned Aerial Vehicle (UAV) and addresses the aerodynamics of the UAV with varied rotor spacing by both numerical simulations and experiments.
Yao Lei, Hengxing Yang, Jifu Hu, Xuan Li, Jiafu Qiu, Yuanfeng Zhang   +5 more
doaj   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

RESEARCH OF THE HIGH HARMONICS INDIVIDUAL BLADE CONTROL EFFECT ON VIBRATIONS CAUSED BY THE HELICOPTER MAIN ROTOR THRUST

Научный вестник МГТУ ГА, 2017
The paper presents numerical results analysis of main rotor vibration due to helicopter main rotor thrust pulsation.The calculation method, the object of research and numerical research results with the aim to reduce the amplitude of the vibrations ...
B. S. Kritsky, R. M. Mirgazov, Le Van Chung   +2 more
doaj  

Numerical Investigation of the Vortex Ring Phenomena in Rotorcraft

Aerospace
Due to their complex aerodynamics, helicopters may enter different dangerous aerodynamic conditions under certain adverse circumstances. In this paper, we examine one such phenomenon—the Vortex Ring State (VRS).
Vytautas Rimša, Mykolas Liugas
doaj   +1 more source

FEATURES OF MODELING THE FLOW AROUND THE HELICOPTER MAIN ROTOR TAKING INTO ACCOUNT ARBITRARY BLADES MOTION

Научный вестник МГТУ ГА, 2019
The article considers the problem of the flow around the helicopter main rotor taking into account blades flapping in the plane of rotation and in the plane of thrust as well as the elastic blades deformation.
V. A. Vershkov, B. S. Kritsky, R. M. Mirgazov   +2 more
doaj   +1 more source

Helicopter Main Rotor Blade Parametric Design for a Preliminary Aerodynamic Analysis Supported by CFD or Panel Method. [PDF]

Materials (Basel), 2022
Kocjan J, Kachel S, Rogólski R.
europepmc   +1 more source

Rotor performance characteristics from an aeroacoustic helicopter wind-tunnel test program [PDF]

An investigation of helicopter rotor noise at model scale was conducted in the Langley 4 by 7 meter tunnel. The program described was the first of a planned three-phase project whose purpose was to examine the characteristic noise mechanism involved in ...
Elliott, J. W., Hoad, D. R., Orie, N. M.
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source