Results 91 to 100 of about 3,775,717 (320)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Effect of Time-varying X-Ray Emission from Stellar Flares on the Ionization of Protoplanetary Disks

The Astrophysical Journal
X-rays have significant impacts on cold, weakly ionized protoplanetary disks by increasing the ionization rate and driving chemical reactions. Stellar flares are explosions that emit intense X-rays and are the unique source of hard X-rays with an energy ...
Haruka Washinoue, Shinsuke Takasao, Kenji Furuya   +2 more
doaj   +1 more source

IRAC Observations of Taurus Pre-Main Sequence Stars

, 2005
We present infrared photometry obtained with the IRAC camera on the Spitzer Space Telescope of a sample of 82 pre-main sequence stars and brown dwarfs in the Taurus star-forming region. We find a clear separation in some IRAC color-color diagrams between
Giovanni Fazio, Kevin Luhman, Lee Hartmann, Lori Allen, Lucas P. W., Lynden-Bell D., Monin J.-L., Nuria Calvet, Paola D’Alessio, Ramiro Franco‐Hernandez, S. T. Megeath   +10 more
core   +2 more sources

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Common Warm Dust Temperatures Around Main-sequence Stars [PDF]

, 2011
We compare the properties of warm dust emission from a sample of main-sequence A-type stars (B8-A7) to those of dust around solar-type stars (F5-K0) with similar Spitzer Space Telescope Infrared Spectrograph/MIPS data and similar ages.
Bryden, G., Morales, Farisa Y., Rieke, G. H., Stapelfeldt, K. R., Su, K. Y. L., Werner, M. W.   +5 more
core   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

The Saccade Main Sequence in Patients With Retinitis Pigmentosa and Advanced Age-Related Macular Degeneration. [PDF]

Invest Ophthalmol Vis Sci, 2023
Guadron L, Titchener SA, Abbott CJ, Ayton LN, van Opstal J, Petoe MA, Goossens J.   +6 more
europepmc   +1 more source

Pre-main-sequence population in NGC 1893 region

, 2012
In this paper we continued our efforts to understand the star formation scenario in and around the young cluster NGC 1893. We used a sample of the young stellar sources (YSOs) identified on the basis of multiwavelength data (optical, near-infrared (NIR),
A.K. Pandey, Adams, Armitage, Balog, Barentsen, Bertoldi, Bertout, Bessell, Bouwman, C. Eswaraiah, Caramazza, Carpenter, Chauhan, Chauhan, Chen, Clarke, Cohen, D.K. Ojha, Dahm, De Vries, Deharveng, Elmegreen, Eswaraiah, Girardi, Gras-Velazquez, Haisch, Hartmann, Hillenbrand, Hillenbrand, J.C. Pandey, Johnson, Johnson, Johnstone, Johnstone, Kenyon, Kessel-Deynet, Koenig, Lawson, Lefloch, Lefloch, M.R. Samal, Maheswar, Matsuyanagi, Meyer, Miao, N. Chauhan, Ojha, Ojha, Pandey, Prisinzano, Robitaille, Roccatagliata, Samal, Sharma, Sharma, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Siess, W.P. Chen, Walter   +60 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source