Results 101 to 110 of about 4,192,840 (340)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Warm Jupiter-sized Planet Transiting the Pre-main-sequence Star V1298 Tau [PDF]

open access: bronze, 2019
Trevor J. David   +16 more
openalex   +1 more source

White dwarf-main sequence binaries from LAMOST: the DR1 catalogue

open access: yes, 2014
Context. White dwarf-main sequence (WDMS) binaries are used to study several different important open problems in modern astrophysics. Aims. The Sloan Digital Sky Survey (SDSS) identified the largest catalogue of WDMS binaries currently known. However,
Jin, Ge   +8 more
core   +1 more source

The Pre - Main Sequence [PDF]

open access: yesInternational Astronomical Union Colloquium, 1993
AbstractThe Pre-Main-Sequence (pre-MS) is defined as the phase following the protostellar stage and ending with the ignition of hydrogen in the stellar core. Models in hydrostatic and thermal equilibrium such as typical “Hayashi track” models are basically adequate to describe the internal structure of pre-MS stars, although for a fraction of pre-MS ...
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

The Blazar Main Sequence

open access: yesThe Astrophysical Journal, 2002
26 pages, 2 eps figures, revised version #2, accepted for pubblication in ...
Cavaliere, A., D'Elia, V.
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Discovery of Metal-poor and Distant Pre–Main Sequence Candidates in WLM with JWST

open access: yesThe Astrophysical Journal Letters
We present the discovery of 12 metal-poor and ​​​distant pre–main sequence (PMS) candidates in the dwarf irregular galaxy Wolf–Lundmark–Melotte ∼968 kpc away, at a present-day metallicity of [Fe/H] ∼ –0.9.
Venu M. Kalari   +6 more
doaj   +1 more source

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