Results 121 to 130 of about 4,192,840 (340)

Effect of Time-varying X-Ray Emission from Stellar Flares on the Ionization of Protoplanetary Disks

The Astrophysical Journal
X-rays have significant impacts on cold, weakly ionized protoplanetary disks by increasing the ionization rate and driving chemical reactions. Stellar flares are explosions that emit intense X-rays and are the unique source of hard X-rays with an energy ...
Haruka Washinoue, Shinsuke Takasao, Kenji Furuya   +2 more
doaj   +1 more source

Surface-gravity determinations for main-sequence B stars [PDF]

Astronomical models for computing surface gravity of B stars from hydrogen line equivalent ...
Peterson, D. M., Strom, S. E.
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Half a Million Binary Stars Identified from the Low-resolution Spectra of LAMOST

The Astrophysical Journal Supplement Series
Binary stars are prevalent yet challenging to detect. We present a novel approach using convolutional neural networks (CNNs) to identify binary stars from low-resolution spectra obtained by the LAMOST survey.
Yingjie Jing, Tian-Xiang Mao, Jie Wang, Chao Liu, Xiaodian Chen   +4 more
doaj   +1 more source

Low-resolution spectroscopy of main sequence stars belonging to 12 Galactic globular clusters [PDF]

, 2010
E. Pancino, M. Rejkuba, M. Zoccali, R. Carrera   +3 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Habitable Zones of Rapidly Rotating Main Sequence A/F Stars

, 2022
John P. Ahlers, Emeline F. Fromont, Ravi Kopparappu, P. Wilson Cauley, Jacob Haqq‐Misra   +4 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A planet within the debris disk around the pre-main-sequence star AU Microscopii. [PDF]

Nature, 2020
Plavchan P, Barclay T, Gagné J, Gao P, Cale B, Matzko W, Dragomir D, Quinn S, Feliz D, Stassun K, Crossfield IJM, Berardo DA, Latham DW, Tieu B, Anglada-Escudé G, Ricker G, Vanderspek R, Seager S, Winn JN, Jenkins JM, Rinehart S, Krishnamurthy A, Dynes S, Doty J, Adams F, Afanasev DA, Beichman C, Bottom M, Bowler BP, Brinkworth C, Brown CJ, Cancino A, Ciardi DR, Clampin M, Clark JT, Collins K, Davison C, Foreman-Mackey D, Furlan E, Gaidos EJ, Geneser C, Giddens F, Gilbert E, Hall R, Hellier C, Henry T, Horner J, Howard AW, Huang C, Huber J, Kane SR, Kenworthy M, Kielkopf J, Kipping D, Klenke C, Kruse E, Latouf N, Lowrance P, Mennesson B, Mengel M, Mills SM, Morton T, Narita N, Newton E, Nishimoto A, Okumura J, Palle E, Pepper J, Quintana EV, Roberge A, Roccatagliata V, Schlieder JE, Tanner A, Teske J, Tinney CG, Vanderburg A, von Braun K, Walp B, Wang J, Wang SX, Weigand D, White R, Wittenmyer RA, Wright DJ, Youngblood A, Zhang H, Zilberman P.   +86 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source