Results 51 to 60 of about 3,873,512 (229)

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Habitable Zone Lifetime of Exoplanets around Main Sequence Stars [PDF]

, 2013
Funding: Dean's Scholarship at the University of East Anglia.The potential habitability of newly discovered exoplanets is initially assessed by determining whether their orbits fall within the circumstellar habitable zone of their star.
Claire, M., Osborn, H., Rushby, Andrew, Watson, A.   +3 more
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Molecular line emissions from pre main sequence objects [PDF]

, 1997
We present some preliminary results obtained with the LWS G.T. programme on the study of young objects driving molecular outflows. In particular, we discuss the importance of molecular emission in these sources and address the role of the H20 ...
Benedettini, M., Caux, E., Ceccarelli, M. C., Clegg, P. E., Correia, J. C., di Giorgio, A. M., Giannini, T., Griffin, M. J., Leeks, S. J., Liseau, R., Lorenzetti, D., Molinari, S., Nisini, B., Saraceno, P., Smith, H., Spinoglio, L., Tomassi, E., White, G. J.   +17 more
core  

Dark stars at the Galactic centre - the main sequence [PDF]

, 2008
In regions of very high dark matter density such as the Galactic centre, the capture and annihilation of WIMP dark matter by stars has the potential to significantly alter their evolution.
Allen, Anders, Angle, Asplund, Audi, Behnke, Bergström, Bergström, Bertone, Bertone, Bertone, Blennow, Blumenthal, Bottino, Bouquet, Bouquet, Bouquet, CDMS Collaboration, Christensen-Dalsgaard, Clowe, Dearborn, Dearborn, Dehnen, Desai, Diemand, Eggleton, Eggleton, Fairbairn, Fairbairn, Faulkner, Faulkner, Faulkner, Forrest, Freese, Freese, Genzel, Genzel, Gerhard, Ghez, Gilliland, Giraud-Heraud, Gnedin, Gondolo, Gondolo, Gould, Gould, Gould, Gould, Griest, Gustafsson, Hansen, Heber, Iocco, Iocco, Joakim Edsjö, Jungman, Kent, Klypin, Komatsu, Krabbe, Krabbe, Levin, Löckmann, Malcolm Fairbairn, Maness, Martins, Merritt, Moore, Morris, Moskalenko, Natarajan, Navarro, Navarro, Pat Scott, Paumard, Paxton, Perets, Perets, Piessens, Pols, Press, Renka, Renzini, Salati, Salati, Sanders, Scott, Scott, Scott, Spergel, Spergel, Spolyar, Steigman, Taoso, Tatsumoto, Testa, Wapstra, Yoon, Zel'dovich, Zhao, Zhu   +100 more
core   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source