Results 71 to 80 of about 3,775,717 (320)

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Summarized effective temperatures scale of main sequence stars and substars

Вісник Астрономічної школи, 2013
The generalized scale of effective temperatures (T_eff) for substars and main sequence stars in the interval spectral types Sp = O8V ÷ T9,5V. Determined the dependence of effective temperatures T_eff from spectral code C_Sp for Sp = O8V ÷ T9,5V ...
M. A. Babenko, V. A. Zakhozhay
doaj   +1 more source

MAIN SEQUENCE EVOLUTION WITH LAYERED SEMICONVECTION [PDF]

The Astrophysical Journal, 2016
ABSTRACT Semiconvection is a form of mixing in thermally unstable regions that are partially stabilized by composition gradients. It has the greatest potential impact on the evolution of the cores of main sequence stars in the mass range –
Kevin Moore, Pascale Garaud
openaire   +3 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

SDSS-IV MANGA: Spatially Resolved Star Formation Main Sequence and LI(N)ER Sequence [PDF]

, 2017
We present our study on the spatially resolved H_alpha and M_star relation for 536 star-forming and 424 quiescent galaxies taken from the MaNGA survey.
Barrera-Ballesteros, J. K., Bizyaev, D., Boquien, M., Brownstein, J., Cano-díaz, M., Cruz-González, I., Hagen, A., Hsieh, B. C., Hsu, C. H., Ibarra, H., Lin, J. H., Lin, Lihwai, Oravetz, D., Pan, H. A., Pan, K., Riffel, R., Simmons, A., Sánchez, S. F., Yan, R., Zhang, K.   +19 more
core   +3 more sources

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Dark stars at the Galactic centre - the main sequence [PDF]

, 2008
In regions of very high dark matter density such as the Galactic centre, the capture and annihilation of WIMP dark matter by stars has the potential to significantly alter their evolution.
Allen, Anders, Angle, Asplund, Audi, Behnke, Bergström, Bergström, Bertone, Bertone, Bertone, Blennow, Blumenthal, Bottino, Bouquet, Bouquet, Bouquet, CDMS Collaboration, Christensen-Dalsgaard, Clowe, Dearborn, Dearborn, Dehnen, Desai, Diemand, Eggleton, Eggleton, Fairbairn, Fairbairn, Faulkner, Faulkner, Faulkner, Forrest, Freese, Freese, Genzel, Genzel, Gerhard, Ghez, Gilliland, Giraud-Heraud, Gnedin, Gondolo, Gondolo, Gould, Gould, Gould, Gould, Griest, Gustafsson, Hansen, Heber, Iocco, Iocco, Joakim Edsjö, Jungman, Kent, Klypin, Komatsu, Krabbe, Krabbe, Levin, Löckmann, Malcolm Fairbairn, Maness, Martins, Merritt, Moore, Morris, Moskalenko, Natarajan, Navarro, Navarro, Pat Scott, Paumard, Paxton, Perets, Perets, Piessens, Pols, Press, Renka, Renzini, Salati, Salati, Sanders, Scott, Scott, Scott, Spergel, Spergel, Spolyar, Steigman, Taoso, Tatsumoto, Testa, Wapstra, Yoon, Zel'dovich, Zhao, Zhu   +100 more
core   +2 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source