Results 21 to 30 of about 361,608 (309)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
1821-2021. Bicentenarul Revoluției conduse de Tudor Vladimirescu
Swedish Journal of Romanian Studies, 2023 The volume 1821-2021. The Bicentennial of the Revolution led by Tudor Vladimirescu, coordinated by Sevastian Cercel and Georgeta Ghionea, brings together 22 papers signed by representatives of the academic and university environment which belong to some ...
Mihaela Bărbieru
doaj +1 more source
Humpback and Fin Whaling in the Gulf of Maine from 1800 to 1918 [PDF]
, 2002 The history of whaling in the Gulf of Maine was reviewed primarily to estimate removals of humpback whales, Megaptera novaeangliae, especially during the 19th century.
Clapham, Phillip J. +4 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
BMC Genomics, 2017 Background Atlantic cod (Gadus morhua), is known to vary genetically across the North Atlantic, Greenland, and Newfoundland. This genetic variation occurs both spatially and temporally through decades of heavy fishing, and is concentrated in three ...
Bryan T. Barney +3 more
doaj +1 more source
Transitions in the morphological features, habitat use, and diet of young-of-the-year goosefish (Lophius americanus) [PDF]
, 2007 This study was designed to improve our understanding of transitions in the early life history and the distribution, habitat use, and diets for young-of-the-year (YOY) goosefish (Lophius americanus) and, as a result, their role in northeastern U.S ...
Able, Kenneth W. +3 more
core
Advanced Science, EarlyView.Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge +21 more
wiley +1 more source
Ecosphere, 2019 Distribution shifts poleward are a widespread response to climate change and can result in altered community composition and interactions among species that previously were geographically isolated.
Marissa D. McMahan +1 more
doaj +1 more source
A study of tagging methods for the sea cucumber Cucumaria frondosa in the waters off Maine [PDF]
, 2006 The sea cucumber fishery in waters off Maine is developing and has recently experienced great increases in landings, corresponding to expanding export markets. Between 1994 and 1996, reported landings ranged from one to three million pounds (Fig. 1).
Chen, Yong +2 more
core
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source