Results 151 to 160 of about 166,212 (332)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

A STUDY OF QUALITY IN THE PROCESS OF SOFTWARE PRODUCT DEVELOPMENT ACCORDING TO MAINTAINABILITY AND REUSABILITY [PDF]

open access: yes
Our research indicates the modality by which algorithm modifications imply intervention in modules where expressions are evaluated or selections of elements are performed, the conclusion being the fact that in order to design robust software, a clear ...
Andy STEFĂNESCU   +2 more
core  

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Framework dan Code Generator Pengembangan Aplikasi Android dengan Menerapkan Prinsip Clean Architecture

open access: yesJurnal Nasional Teknik Elektro dan Teknologi Informasi, 2020
Aflah Taqiu Sondha   +3 more
doaj   +1 more source

Advanced EVA system design requirements study [PDF]

open access: yes
The results are presented of a study to identify specific criteria regarding space station extravehicular activity system (EVAS) hardware requirements. Key EVA design issues include maintainability, technology readiness, LSS volume vs. EVA time available,
Woods, T. G.
core   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Experiences with the use of MERODE in the development of a web based application. [PDF]

open access: yes
This article presents an experience report on using MERODE as the business modeling method for the development of a web application. MERODE has several advantages as improving the flexibility and maintainability of applications and the possibility of ...
Chong, Karina   +2 more
core  

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