Results 151 to 160 of about 13,846 (260)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
QUPER-MAn : benchmark-guided target setting for maintainability requirements
Maintainable source code is essential for sustainable development. Yet, many studies show that maintainability often receives less attention than it deserves.
Larsson, Martin +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Bayesian Belief Networks in Reliability
, 2012 Tutorial tenuto al 58th Annual Reliability and Maintainability Symposium (RAMS ...
PORTINALE, Luigi
core
Better Python Programming for all: With the focus on Maintainability
<p>This study aims to enhance the maintainability of code generated by Large Language Models (LLMs), with a focus on the Python programming language.
anonymous
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
MAINTAINABILITY ISSUES IN BUILDING DESIGN AND OPERATION
, 2015 This research investigates whether maintainability issues should be addressed in the design phase of facilities. Facility managers are responsible for the maintenance and operation of a building, and expect designers to include maintainability as one the
Sohi, Armin Jalali
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Ergonomics Contribution in Maintainability [Elektronisk resurs]
, 2017 The objective of this paper is to describe an ergonomics contribution in maintainability. The economical designs, inputs and training helps to increase themaintainability indicators for industrial devices. This analysis can be helpful, among other cases,
Seneviratne, Dammika, +2 more
core