Results 161 to 170 of about 1,301 (285)

Tuberculous Meningitis during Pregnancy: Maintaining a High Index of Suspicion

Obstetrics and Gynaecology Cases - Reviews, 2022
Christodoulides Alexei, Petrucciani Alexa, Frasier Raizel M, Roesler Anna   +3 more
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Structural Design of a Nanogel Reaction Device with Emphasis on Temperature-Field Uniformity. [PDF]

Materials (Basel)
Tang Z, Wang M, Liu J, Zeng Z, Guo J, Yu X, Li L.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Novel Framework to Assess Clinical Information in Digital Health Technologies: Cross-Sectional Survey Study. [PDF]

JMIR Med Inform
Fadahunsi KP, Wark PA, Mastellos N, Neves AL, Gallagher J, Majeed A, Car J.   +6 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Ghost Echoes Revealed: Benchmarking Maintainability Metrics and Machine Learning Predictions Against Human Assessments

As generative AI is expected to increase global code volumes, the importance of maintainability from a human perspective will become even greater. Various methods have been developed to identify the most important maintainability issues, including ...
Ezzouhri, Marwa, Borg, Markus, Tornhill, Adam   +2 more
core  

Refactoring code to increase readability and maintainability

, 2013
In this paper, I present a case study on the tool-mediated refactoring process and its effects, in terms of software metrics and performance, on an educational video game. The game is Museum Assistant: Design an Exhibit, which was released in May 2012 by
Dibble, Christopher
core  

Osseous Resective Surgery: The Past, the Present and the Future. [PDF]

J Periodontal Res
Aimetti M, Carnevale G.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source