Results 141 to 150 of about 1,871,440 (296)

PROPOSED PROCEDURE FOR OPTIMAL MAINTENANCE SCHEDULING UNDER EMERGENT FAILURES

, 2020
Abbas Al‐Refaie, Heba Al-shalaldeh, Natalija Lepkova   +2 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An Integrated Risk-Informed Multicriteria Approach for Determining Optimal Inspection Periods for Protective Sensors. [PDF]

Sensors (Basel)
Mateus RJG, Assis R, Carmona Marques P, Martins ADB, Rodrigues JCA, Pinto FS.   +5 more
europepmc   +1 more source

Role of nuclear lamina-cytoskeleton interactions in the maintenance of cellular strength

, 2006
Frederik Houben, F. C. S. Ramaekers, Luc H. E. H. Snoeckx, Jos L. V. Broers   +3 more
openalex   +2 more sources

Management and outcomes of patients on maintenance dialysis during the first and second wave of the COVID-19 pandemic in Geneva, Switzerland 

, 2021
Ido Zamberg, Thomas A. Mavrakanas, Thomas Ernandez, Vincent Bourquin, Michael J. Zellweger, Nicolas Marangon, Françoise Raimbault, Rebecca Winzeler, Anne Iten, Nathalie Hammer, Belén Ponte, Sebastian Carballo, Pierre‐Yves Martin, Patrick Saudan   +13 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dietary Patterns During Weight Loss Maintenance vs. Weight Regain: A Secondary Analysis of the Look AHEAD Trial. [PDF]

Nutrients
Prater MC, Greenway FL, White U.
europepmc   +1 more source

Design of multi-component periodic maintenance programs with single-component models

, 2018
Joachim Arts, Rob Basten
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Maintenance therapy after first-line therapy for ovarian cancer: Quantitative effectiveness. [PDF]

CA Cancer J Clin
Campos SM, DiSilvestro J, Blank SV.
europepmc   +1 more source