The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Moisture ingress in a hospital medical air system secondary to dryer failure leading to service disruption. [PDF]
Summers J +6 more
europepmc +1 more source
Development of Maintenance Technology and Role of Maintenance Engineers
openaire +2 more sources
Cell surface CD11c as a neutrophil aging marker molecule
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Comparative Evaluation of Annual and Comprehensive Maintenance Contracts for Reducing Medical Equipment Downtime in a Tertiary Care Hospital: An Observational Audit. [PDF]
Mahto S +4 more
europepmc +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Sensing Technologies in Industrial Defect Detection. [PDF]
Liu P.
europepmc +1 more source
CAR-T Cell Therapy: Engineering Remission in Refractory Myeloma. [PDF]
Sperling AS.
europepmc +1 more source
Chemical organizations as a conceptual tool: from synthetic biology to interdisciplinary systems and back. [PDF]
Veloz T, Jendreiko C.
europepmc +1 more source
Automated Road Marking Wear Assessment via Multimodal Fusion of LiDAR Intensity and YOLOv11 Semantic Segmentation. [PDF]
Chen PY +5 more
europepmc +1 more source

