Results 81 to 90 of about 1,371,472 (303)

Safety and maintenance engineering: A compilation [PDF]

A compilation is presented for the dissemination of information on technological developments which have potential utility outside the aerospace and nuclear communities.

core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessing cyber-physical systems to balance maintenance replacement policies and optimise long-run average costs for aircraft assets

IET Cyber-Physical Systems, 2018
Many aircraft assets are subject to both preventive (scheduled) and corrective (unscheduled) replacement policies to ensure adequate levels of reliability and availability.
Marco Andreacchio, Abdelghani Bekrar, Abdelghani Bekrar, Rachid Benmansour, Damien Trentesaux   +4 more
doaj   +1 more source

Activities of the Aeronautics and Space Engineering Board Commission on Engineering and Technical Systems [PDF]

The agenda of the Aeronautics and Space Engineering Board meeting is reviewed. Items discussed included; engineering and technical requirements of the space station, NASA's altitude wind tunnel, rocket engine casings, advanced flight vehicle technology ...

core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Impact of Integrating Information Technology With Operational Technology in Physical Assets: A Literature Review

IEEE Access
The convergence of information technology (IT) with operational technology (OT), within physical assets can enhance performance but also presents challenges due to higher performance expectations and increased complexity.
Arno Kok, Alberto Martinetti, Jan Braaksma   +2 more
doaj   +1 more source

Deformation analysis of deep foundation pit in soft soil area considering space–time effect

The Journal of Engineering, 2019
Taking the deep foundation pit project of Taojiazhai in Shanghai as the background, combined with the real-time monitoring data, the data variation law of several monitoring items during the excavation of foundation pit are analysed.
Lide Shi, Wanrong Yu, Lei Fu
doaj   +1 more source

Engineering works and the tidal Chesapeake [PDF]

, 1972
The tidal tributaries of the ocean and coastal areas of the mid-Atlantic region and the ecological significance of engineering projects are discussed. The effects of engineering works on maritime environments and resources, with the Chesapeake Bay as the
Hargis, W. J., Jr.
core   +2 more sources

Data-Driven Application Maintenance: Views from the Trenches

, 2018
In this paper we present our experience during design, development, and pilot deployments of a data-driven machine learning based application maintenance solution.
Misra, Janardan, Podder, Sanjay, Rawat, Divya, Savagaonkar, Milind, Sengupta, Shubhashis   +4 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source