Results 81 to 90 of about 6,900,710 (296)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Design and application of condition monitoring for power transmission and transformation equipment based on smart grid dispatching control system

The Journal of Engineering, 2019
With the increasing demand for power supply reliability and the transmission equipment is an important part of power generation, transmission and distribution engineering.
Gui-Ping Zhou, Huan-Huan Luo, Wei-Chun Ge, Yi-Ling Ma, Shi Qiu, Li-Na Fu   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

State-of-the-art of 'Lean' in the aviation maintenance, repair, and overhaul industry [PDF]

, 2011
The increasing need for maintenance, repair, and overhaul (MRO) organizations to meet customers’ demands in quality and reduced lead times is key to its survival within the aviation industry.
Baines, Tim S., Lightfoot, Howard, P Ayeni, Lightfoot, H., H Lightfoot, Ball, Peter D., Baines, T., P Ball, Ball, P., T Baines, Ayeni, P.   +10 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The Impact of Integrating Information Technology With Operational Technology in Physical Assets: A Literature Review

IEEE Access
The convergence of information technology (IT) with operational technology (OT), within physical assets can enhance performance but also presents challenges due to higher performance expectations and increased complexity.
Arno Kok, Alberto Martinetti, Jan Braaksma   +2 more
doaj   +1 more source

Assessing cyber-physical systems to balance maintenance replacement policies and optimise long-run average costs for aircraft assets

IET Cyber-Physical Systems, 2018
Many aircraft assets are subject to both preventive (scheduled) and corrective (unscheduled) replacement policies to ensure adequate levels of reliability and availability.
Marco Andreacchio, Abdelghani Bekrar, Abdelghani Bekrar, Rachid Benmansour, Damien Trentesaux   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Design and implementation of a CPS-based predictive maintenance and automated management platform

IET Cyber-Physical Systems, 2019
The concept of cyber-physical systems (CPSs) is a core technology indispensable to Industry 4.0. The development of an intelligent automatic operational management platform is presented in this study. The platform is used to collect on-site data, provide
Huei-Yung Lin, Fang-Ning Yang, Fang-Ning Yang   +2 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source