Results 121 to 130 of about 15,821,124 (295)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Surrogate-based flowsheet model maintenance for Digital Twins

Digital Chemical Engineering
Digital Twins (DTs) are transforming industrial processes by providing virtual models that mirror physical systems, enabling real-time monitoring and optimization.
Balázs Palotai, Gábor Kis, János Abonyi, Ágnes Bárkányi   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Maintenance Optimization of High Voltage Substation Model

Advances in Electrical and Electronic Engineering, 2008
The real system from practice is selected for optimization purpose in this paper. We describe the real scheme of a high voltage (HV) substation in different work states. Model scheme of the HV substation 22 kV is demonstrated within the paper. The scheme
Radim Bris, Jan Gala
doaj  

Severity-Aware Drift Adaptation for Cost-Efficient Model Maintenance

AI
Objectives: This paper introduces an adaptive learning framework for handling concept drift in data by dynamically adjusting model updates based on the severity of detected drift.
Khrystyna Shakhovska, Petro Pukach
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

ENHANCED MAINTENANCE PROBLEM RECOGNITION TECHNIQUES AND ITS APPLICATION TO PALM OIL MILLS

Journal of ICT, 2008
This paper discusses the application of enhanced maintenance problem recognition techniques. The main contribution of this study is the proposed combined techniques, namely snapshot model, failure mode, effect and criticality analysis (FMECA), Pareto ...
Abd Samad Hasan Basari, N.S Herman, Siti Azirah Asmai   +2 more
doaj  

Predictive utility of the multi-theory model in physical activity initiation and maintenance intentions among maintenance hemodialysis patients: a cross-sectional study

Frontiers in Psychology
BackgroundPhysical activity (PA) reduces cardiovascular and all-cause mortality in patients undergoing maintenance hemodialysis (MHD); however, PA participation among this population remains suboptimal.
Rui Zhang, Yuchen Chu, Tianxin Liu, Peiying Wang, Yunfeng Li, Jinrong Gai   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source