Results 91 to 100 of about 44,748 (260)

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Unveiling the impact of heat and drought stress on plant reproductive tissues

Environmental and Experimental Botany
Reproductive development in plants is highly sensitive to heat and drought stress, which are exacerbated by climate change and pose significant threats to global crop productivity.
Yueheng Zhou, Muhammad Ali, Xiaohui Ma, Tianxia Yang   +3 more
doaj   +1 more source

Innovative approaches to integrating gender into conventional maize breeding: lessons from the Seed Production Technology for Africa project. [PDF]

Front Sociol, 2023
Voss RC, Cairns JE, Olsen M, Muteti FN, Magambo Kanyenji G, Hamadziripi E, Ligeyo D, Mashingaidze K, Collinson S, Wanderi S, Woyengo V.   +10 more
europepmc   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Genome-Wide Meta-Analysis of QTLs Associated with Root Traits and Implications for Maize Breeding. [PDF]

Int J Mol Sci, 2023
Karnatam KS, Chhabra G, Saini DK, Singh R, Kaur G, Praba UP, Kumar P, Goyal S, Sharma P, Ranjan R, Sandhu SK, Kumar R, Vikal Y.   +12 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Accounting for spatial trends in multi-environment diallel analysis in maize breeding. [PDF]

PLoS One, 2021
Ferreira Coelho I, Peixoto MA, Marçal TS, Bernardeli A, Silva Alves R, de Lima RO, Reis EFD, Bhering LL.   +7 more
europepmc   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize

Plant Stress
Fusarium graminearum-induced ear rot may lead to severe yield losses and mycotoxin contamination, which threaten global maize production. To dissect resistance mechanisms, we integrated a genome-wide association study (GWAS) of 420 maize inbred lines ...
Aiguo Su, Senlin Xiao, Zhiyong Li, Sairu Duan, Shuaishuai Wang, Haixia Zhang, Ruyang Zhang, Jinfeng Xing, Chunhui Li, Xiaqing Wang, Yanxin Zhao, Shuai Wang, Xuan Sun, Fengge Wang, Yang Yang, Yuandong Wang, Tianjun Xu, Xueyuan Zhang, Ronghuan Wang, Wei Song, Jiuran Zhao   +20 more
doaj   +1 more source