Results 51 to 60 of about 7,978,447 (307)

High‐Intensity Interval Training for Patients With Cardiovascular Disease—Is It Safe? A Systematic Review

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Cardiac rehabilitation (CR) for patients with cardiovascular disease has traditionally involved low‐ to moderate‐intensity continuous aerobic exercise training (MICT). There is growing and robust evidence that high‐intensity interval training (
Michael A. Wewege, Dohee Ahn, Jennifer Yu, Kevin Liou, Andrew Keech   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Blood pressure and the risk of major adverse cardiovascular events among firefighters

Journal of Hypertension, 2020
Objective: No long-term follow-up study has investigated the effect of blood pressure (BP) on cardiovascular disease mortality and morbidity in firefighters. To investigate the effects of BP on the risk of major adverse cardiovascular events (MACEs) using a national representative population-matched cohort.
Juhwan, Noh, Chan Joo, Lee, Dae-Sung, Hyun, Woojin, Kim, Mi-Ji, Kim, Ki-Soo, Park, Sangbaek, Koh, Sei-Jin, Chang, Changsoo, Kim, Sungha, Park   +9 more
openaire   +3 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Standardized risk-stratified cardiac assessment and early posttransplant cardiovascular complications in kidney transplant recipients

Frontiers in Cardiovascular Medicine
IntroductionCardiovascular disease (CVD) is the leading cause of morbidity and mortality in kidney transplant recipient (KTR). There is a dearth of standardized guidelines on optimal cardiovascular evaluation of transplant candidates.MethodsThis single ...
Silvie Rajnochova Bloudickova, Bronislav Janek, Karolina Machackova, Petra Hruba   +3 more
doaj   +1 more source

Risk of Major Adverse Cardiovascular Events Following Nicotinamide Exposure

JAMA Dermatology
ImportanceNicotinamide metabolites have recently been implicated in increased risk of major cardiovascular events (MACE). Supportive data about clinical risk of MACE for nicotinamide users is lacking.ObjectiveTo determine whether nicotinamide use results in an increase of MACE.Design, Setting, and ParticipantsThis study used retrospective electronic ...
Lee Wheless, Ranya Guennoun, Basia Michalski-McNeely, Katlyn M. Gonzalez, Rachel Weiss, Siwei Zhang, Lydia Yao, Chris Madden, Hua-Chang Chen, Jefferson L. Triozzi, Ran Tao, Otis Wilson, Quinn S. Wells, Adriana Hung, Kristin Bibee, Rebecca I. Hartman, Yaomin Xu, Sumitra Muralidhar, Jennifer Moser, Jennifer E Deen, Philip S Tsao, J. Michael Gaziano, Elizabeth Hauser, Amy Kilbourne, Michael Matheny, Dave Oslin, Deepak Voora, Jessica V Brewer, Mary T Brophy, Kelly Cho, Lori Churby, Scott L DuVall, Saiju Pyarajan, Robert Ringer, Luis E Selva, Shahpoor (Alex) Shayan, Brady Stephens, Stacey B Whitbourne, Themistocles L Assimes, Adriana Hung, Henry Kranzler   +40 more
openaire   +3 more sources

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups

BMC Medicine, 2019
Background The role of aspirin in primary prevention of cardiovascular disease (CVD) remains unclear. We aimed to investigate the benefit-risk ratio of aspirin for primary prevention of CVD with a particular focus on subgroups.
Georg Gelbenegger, Marek Postula, Ladislav Pecen, Sigrun Halvorsen, Maciej Lesiak, Christian Schoergenhofer, Bernd Jilma, Christian Hengstenberg, Jolanta M. Siller-Matula   +8 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source