Results 161 to 170 of about 10,024,591 (280)

Amputations in Sepsis Patients: A Population‐Based Cohort Study of Rates and Risk Factors

ANZ Journal of Surgery, EarlyView.
This cohort study of 158 842 sepsis patients revealed that between 2015 and 2021 in NSW, 11 in every 1000 adult sepsis patients and two in every 1000 paediatric sepsis patients underwent amputation. Male adults under 85 years with diabetes or peripheral arterial disease were at a higher risk of amputation. ABSTRACT Background A rare and serious adverse
Khalia Ackermann, Nanda Aryal, Johanna Westbrook, Ling Li   +3 more
wiley   +1 more source

Retrograde access revascularization in chronic limb threatening ischaemia. [PDF]

CVIR Endovasc
Gao Y, Patrone L, Davies N, Papadopoulou A, Woodward N, Tsui J, Portou M, Benaragama S, von Stempel C.   +8 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Imaging-Based Markers of Sarcopenia in Lower Limb Ischemia: A Systematic Review. [PDF]

J Clin Med
Grzelak O, Bobrowski I, Halman J, Gniedziejko M, Siemiński M, Wojciechowski J.   +5 more
europepmc   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Frailty and Adverse Outcomes After Endovascular Revascularization for Chronic Limb-Threatening Ischemia: A Systematic Review and Exploratory Meta-Analysis. [PDF]

Cureus
Almomany M, Reingold Y, Al-Yaghshi A, Alsayyed FS, Almajali N, Mahmoud H, Alshyyab RA, Jaber MF, Al-Hijazin M, Jaber A, Al-Shehari GA.   +10 more
europepmc   +1 more source

Association of altered body composition with cardiac wasting in cancer with and without cardiotoxic therapy

British Journal of Pharmacology, EarlyView.
Created in BioRender: Scientific Figure and Illustration Software. Background and Purpose In advanced cancer, associations among changes in body composition, cardiac wasting and prior cardiotoxic anticancer therapy have not been investigated. Experimental Approach Using bioelectrical impedance analysis (BIA), body composition was measured in 206 ...
Sara Hadzibegovic, Jonathan L. Hella, Jan Porthun, Alessia Lena, Danara Krug, Iulia Baluta, Ursula Wilkenshoff, Amir A. Mahabadi, Matthias Totzeck, Tienush Rassaf, Stefan D. Anker, Wolfram Doehner, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Barry J. A. Laird, Richard J. E. Skipworth, John G. F. Cleland, Christian Oeing, Stephan von Haehling, Ulf Landmesser, Markus S. Anker   +21 more
wiley   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

The TMAO Metabolic Axis in Vascular Disease: A Position Paper on Redox Mechanisms and Priorities for Clinical Translation. [PDF]

Antioxidants (Basel)
Miceli F, Caradonna E, Panzano C, Mansour W, Ferrara F, Costantino L, Setacci C, di Marzo L.   +7 more
europepmc   +1 more source