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Plasma Extracellular Vesicle Serpin G1 and CD14 Levels Are Associated With Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients Undergoing Femoral Endarterectomy [PDF]

European Journal of Vascular and Endovascular Surgery, 2023
Objective: Plasma extracellular vesicles (EV) are an emerging source of biomarkers for diagnosis and prognosis of cardiovascular disease (CVD). Risk stratification for common adverse events such as major adverse limb events (MALE) and major adverse ...
Gerard Pasterkamp, Nathalie Timmerman, Gert Jan de Borst   +2 more
exaly   +1 more source

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Tirzepatide and major adverse limb events: Insights from a multicenter real-world analysis in PAD and diabetes patients.

Diabetes Research and Clinical Practice
AIMS Peripheral artery disease (PAD) is a major diabetic complication and a leading cause of amputation. While GLP-1 receptor agonists (GLP-1 RAs) provide cardiovascular and limb protection, the impact of tirzepatide, a dual GLP-1/GIP receptor agonist ...
Jheng-Yan Wu, Wan-Ling Tu, Tsung Yu, Kuang-Ming Liao, Yu-Min Lin   +4 more
semanticscholar   +1 more source

Effect of glucagon-like peptide-1 receptor agonists on the risk of major adverse limb events in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized clinical trials.

Endocrinología Diabetes y Nutrición
OBJECTIVE To evaluate the effect of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on the risk of major adverse limb events (MALE). METHODS We conducted a systematic review and meta-analysis of randomized clinical trials assessing the effects of ...
F. Garagoli, W. Masson, L. Barbagelata, M. Lobo   +3 more
semanticscholar   +1 more source

Dual anti-platelet therapy after iliac artery stenting improves limb salvage and freedom from major adverse limb events compared to single antiplatelet therapy.

Annals of Vascular Surgery
OBJECTIVE Antiplatelet therapy is recommended by the Society for Vascular Surgery guidelines for patients following peripheral arterial intervention. However, there are no guidelines regarding the role of dual antiplatelet therapy (DAPT) following iliac ...
David P. Ebertz, M. Smeds, Faisal Aziz, S. Bose   +3 more
semanticscholar   +1 more source

Effect of a multidisciplinary team approach in patients with diabetic foot ulcers on major adverse limb events (MALEs): systematic review and meta-analysis for the development of the Italian guidelines for the treatment of diabetic foot syndrome

Acta Diabetologica
The treatment of patients with diabetic foot ulcers (DFUs) is extremely complex, requiring a comprehensive approach that involves a variety of different healthcare professionals. Several studies have shown that a multidisciplinary team (MDT) approach is useful to achieve good clinical outcomes, reducing major and minor amputation and increasing the ...
Meloni M, Giurato L, Monge L, Miranda C, Scatena A, Ragghianti B, Silverii GA, Vermigli C, De Cassai A, Volpe A, Tramonta R, Medea G, Bordieri C, Falcone M, Stefanon L, Bernetti A, Cappella C, Gargiulo M, Lorenzoni V, Scevola G, Stabile E, Da Ros R, Murdolo G, Bianchini E, Gaggia F, Gauna C, Romeo F, Apicella M, Mantuano M, Monami M, Uccioli L, Panel of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome and on behalf of SID and AMD   +31 more
openaire   +7 more sources

Geriatric Nutritional Risk Index as a Predictor of Major Adverse Limb Events in Older Patients With Peripheral Artery Disease: A Prospective Cohort Study.

Journal of Clinical Nursing
BACKGROUND AND AIM The geriatric nutritional risk index (GNRI) predicts adverse outcomes in chronic diseases, but its prognostic value for major adverse limb events (MALE) in elderly patients with peripheral artery disease (PAD) remains unverified; thus,
Xiao-Yu Liu, Xin-Jun Liu, Qin Chen, Qing-Ran Li, Lu Tang, Jing Li, Xiaoli Hu, Xi Yang, Mei-Hong Shi   +8 more
semanticscholar   +1 more source

Leisure-time physical activity reduces the risk of major adverse limb events in patients with established cardiovascular disease, while occupational activity shows no protective effect

European Heart Journal
Leisure-time physical activity (LTPA) decreases the risk of major adverse cardiovascular events (MACE) via anti-inflammatory effects and the modification of classical risk factors such as hypertension, hypercholesterolemia and obesity, and by ...
T. Reitsma, J. Dorresteijn, M. Teraa, F. Visseren, S. Hageman   +4 more
semanticscholar   +1 more source

Long-Term Outcomes and Major Adverse Limb Events in Claudicants Undergoing Iliac Artery Stenting Versus Superficial Femoral Artery Stenting.

Annals of Vascular Surgery
OBJECTIVE Iliac artery and superficial femoral artery (SFA) stenting are common procedures to relieve claudication. We investigate major adverse limb events (MALE), follow-up symptoms and peri-operative complications between the two interventions ...
Richard Shi, Saranya S. Sundaram, A. Tanious   +2 more
semanticscholar   +1 more source

Predictive factors and models for major adverse cardiovascular and limb events in patients with peripheral arterial disease.

VASA. Zeitschrift fur Gefasskrankheiten
Background: Peripheral arterial disease (PAD) is associated with an increased risk of major adverse cardiovascular and limb events. However, the factors influencing major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in ...
Pan Song, Huarong Xiong, Xiao-Yan Quan, Qin Chen, Dan Wang, Xiao-Yu Liu, Mei-Hong Shi   +6 more
semanticscholar   +1 more source

Vein Harvest Technique Is Not Associated with Major Adverse Limb Events.

Journal of Vascular Surgery
BACKGROUND Benefits of vein conduits in lower extremity bypasses (LEB) are known but there is debate about the harvesting technique. We aimed to compare the impact of conduit harvest on major adverse limb event (MALE) and MALE-free survival (MFS ...
Andrew Lee, Catherine C. Go, F. Annie, R. Butcher, Mohammad H. Eslami   +4 more
semanticscholar   +1 more source