Results 121 to 130 of about 193,331 (298)

Major depressive disorder

Human Brain Mapping, 2009
U. Windhorst, H Boeker, N. Hirokawa, M C Hirsch, M.D. Binder   +4 more
openaire   +2 more sources

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Major Depressive Disorder in Adolescence: A Brief Review of the Recent Treatment Literature [PDF]

, 2003
Robert Milin, Selena Walker, Joy Chow
openalex   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression.

, 2002
Mark Hyman Rapaport, Rachel Maddux
openalex   +2 more sources

Subthreshold depression as a risk indicator for major depressive disorder: a systematic review of prospective studies [PDF]

, 2004
Pim Cuijpers, Filip Smit
openalex   +1 more source

Direct and Low‐Temperature Regeneration of Degraded LiFePO₄ Cathodes at Ambient Conditions Using Green and Sustainable Deep Eutectic Solvent

Advanced Science, EarlyView.
Computational predictions identify ethylene glycol and lithium chloride as optimal components for a green deep eutectic solvent (DES). And further investigations determine the optimal reaction conditions and process parameters for DES treatment of spent lithium iron phosphate (S‐LFP).
Yixin Lin, Tiansheng Wang, Chaochao Gao, Xiaoxuan Zhang, Wen Yu, Mi Wang, Chao Yang, Jiaheng Zhang   +7 more
wiley   +1 more source

Triiodothyronine Addition to Paroxetine in the Treatment of Major Depressive Disorder [PDF]

, 2004
Bente C. Appelhof, J. Brouwer, Richard van Dyck, Eric Fliers, Witte J.G. Hoogendijk, Jochanan Huyser, Aart H. Schene, Jan G.P. Tijssen, Wilmar M. Wiersinga   +8 more
openalex   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source